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Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method

文献类型：期刊论文

作者Li, Jing1,2; Qin, Qiao1,3; Zha, Sheng-Hua4; Zhao, Qing-Sheng3; Li, Hang3; Liu, Lu-Peng1,3; Hou, Shou-Bu3; Zhao, Bing3
刊名MOLECULES
出版日期2022-10-01
卷号27期号:20页码:17
关键词Forsythia suspensa leaves beta-cyclodextrins response surface methodology stability antioxidant activity
DOI10.3390/molecules27207055
英文摘要In this study, a green process of beta-cyclodextrin (beta-CD)-assisted extraction of active ingredients from Forsythia suspensa leaves was developed. Firstly, the optimal process of extraction was as follows: the ratio between Forsythia suspensa leaves and beta-CD was 3.61:5, the solid-liquid ratio was 1:36.3, the temperature was 75.25 degrees C and the pH was 3.94. The yields of forsythoside A, phillyrin and phillygenol were 11.80 +/- 0.141%, 5.49 +/- 0.078% and 0.319 +/- 0.004%, respectively. Then, the structure characteristics of the beta-CD-assisted extract of Forsythia suspensa leaves (FSE-beta-CD) were analyzed using powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and molecular docking to demonstrate that the natural active products from Forsythia suspensa leaves had significant interactions with the beta-CD. Additionally, the loss of forsythoside A from aqueous FSE-CD at 80 degrees C was only 12%, compared with Forsythia suspensa leaf extract (FSE) which decreased by 13%. In addition, the aqueous solubility of FSE-CD was significantly increased to 70.2 g/L. The EC50 for scavenging DPPH and ABTS radicals decreased to 28.98 ug/mL and 25.54 ug/mL, respectively. The results showed that the beta-CD-assisted extraction process would be a promising technology for bioactive compounds extracted from plants.
WOS关键词THUNB. VAHL ; COMPONENTS ; COMPLEXES
资助项目Hebei University of Economics and Business[B20221002] ; [JXT2020YB05]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000873263200001
资助机构Hebei University of Economics and Business
源URL[http://ir.ipe.ac.cn/handle/122111/55238]  
专题中国科学院过程工程研究所
通讯作者Zha, Sheng-Hua; Zhao, Qing-Sheng
作者单位1.Hebei Univ Econ & Business, Coll Biosci & Engn, Shijiazhuang 050061, Hebei, Peoples R China
2.Hebei Univ Sci & Technol, Coll Food & Biol, Shijiazhuang 050018, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Beijing Tong Ren Tang Hlth Pharmaceut Co Ltd, Beijing 100085, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jing,Qin, Qiao,Zha, Sheng-Hua,et al. Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method[J]. MOLECULES,2022,27(20):17.
APA Li, Jing.,Qin, Qiao.,Zha, Sheng-Hua.,Zhao, Qing-Sheng.,Li, Hang.,...&Zhao, Bing.(2022).Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method.MOLECULES,27(20),17.
MLA Li, Jing,et al."Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method".MOLECULES 27.20(2022):17.

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来源：过程工程研究所

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