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Aloe Vera-Fermented Beverage Ameliorates Obesity and Gut Dysbiosis in High-Fat-Diet Mice

文献类型：期刊论文

作者Fu, Shijie1; Dang, Yanting2; Xu, Huilin1; Li, Aimin2; Zhou, Xiaoman1; Gao, Xiaodong3; Li, Zijie1
刊名FOODS
出版日期2022-11-01
卷号11期号:22页码:15
关键词obesity fermented beverages Aloe vera gut microbiota
DOI10.3390/foods11223728
英文摘要Aloe vera has been proven to have various medicinal properties, including anti-inflammatory and anti-obesity functions. However, the effects of Aloe vera-fermented beverages (AFB) on obesity and its complications are still not clear. In this study, HepG2 cells in high-fat environment and high-fat diet (HFD) mice were used to investigate the potential obesity-preventing function of AFB. We found that AFB intervention decreased the amount of lipid droplets of HepG2 cells, suppressed the body weight gain and adipose accumulation, and reduced the serum contents of total cholesterol (TC), alanine aminotransferase (ALT), and interleukin 10 (IL-10) of HFD-mice. In addition, it also changed the composition of the gut microbiota. The ratio of Firmicutes/Bacteroidetes was decreased, while the relative abundance of Muribaculaceae, Alistipes and Rikenellaceae RC9_gut_group was increased after the administration of AFB compared with HFD-mice. These results demonstrated that AFB can prevent diet-induced obesity (DIO) and provides a new option to modulate obesity-related gut dysbiosis.
WOS关键词GENE-EXPRESSION ; ADIPOSE-TISSUE ; MICROBIOTA ; ACCUMULATION
资助项目National Natural Science Foundation of China[32171475] ; Natural Science Foundation of Jiangsu Province[BK20210465] ; Shandong Provincial Major Scientific and Technological Innovation Project[2019JZZY011006]
WOS研究方向Food Science & Technology
语种英语
WOS记录号WOS:000887215300001
出版者MDPI
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Shandong Provincial Major Scientific and Technological Innovation Project
源URL[http://ir.ipe.ac.cn/handle/122111/55818]  
专题中国科学院过程工程研究所
通讯作者Li, Zijie
作者单位1.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China
2.Guozhen Hlth Technol Beijing Co Ltd, Beijing 102206, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Shijie,Dang, Yanting,Xu, Huilin,et al. Aloe Vera-Fermented Beverage Ameliorates Obesity and Gut Dysbiosis in High-Fat-Diet Mice[J]. FOODS,2022,11(22):15.
APA Fu, Shijie.,Dang, Yanting.,Xu, Huilin.,Li, Aimin.,Zhou, Xiaoman.,...&Li, Zijie.(2022).Aloe Vera-Fermented Beverage Ameliorates Obesity and Gut Dysbiosis in High-Fat-Diet Mice.FOODS,11(22),15.
MLA Fu, Shijie,et al."Aloe Vera-Fermented Beverage Ameliorates Obesity and Gut Dysbiosis in High-Fat-Diet Mice".FOODS 11.22(2022):15.

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来源：过程工程研究所

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