Biomineralized dipeptide self-assembled hydrogel with ultrahigh mechanical strength and osteoinductivity for bone regeneration
文献类型：期刊论文
| 作者 | Hao, Linna1,2; Wang, Anhe1,3; Fu, Junjie2; Liang, Sen1,3; Han, Qingquan1,3; Jing, Yafeng1,3; Li, Jieling1,3; Li, Qi1,3; Bai, Shuo1; Seeberger, Peter H.4 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2023-01-20 |
| 卷号 | 657页码:10 |
| 关键词 | Peptide hydrogel Self-assembly Biomineralization Mechanical performance Bone regeneration |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2022.130622 |
| 英文摘要 | Peptide self-assembled hydrogels are ideal scaffolds for three-dimentional cell culture and tissue engineering due to their native extracellular matrix enabling the transport of nutrients as well as the cells growth and expansion. However, the use of peptide hydrogels in the hard tissues regeneration such as alveolar and skull bone has been largely unexplored, hindered by the insufficient mechanical strength and osteogenesis activity. Herein, peptide self-assembled nanostructures are used as templates to emulate natural biomineralization process. The vaterite nanoparticles loaded with thermolysin act as a role of mature osteoblasts secreting collagen fibrils to initiate dipeptide self-assembly as biomimetic extracellular matrix. Meanwhile, the vaterite nanoparticles with a high specific surface area form strong intermolecular and interfacial interaction with hydrogel networks, acting as a cross-linker to achieve extrafibrillar mineralization. Moreover, vaterite nanoparticles function as a mineral reservoir to release Ca2+, inducing intrafibrillar mineralization, further enhancing the mechanical property. The resulting hydrogel exhibits an unprecedently high value of storage modulus (473 kPa), excellent biocompatibility and osteoinductivity. In rat calvarial defect model, the hydrogel significantly accelerates regeneration of osteogenesis tissue, thus indicating the potential of such peptide hydrogels for application in bone regeneration. |
| WOS关键词 | HYDROXYCARBONATE APATITE ; VATERITE NANOPARTICLES ; SCAFFOLDS ; PEPTIDES ; FABRICATION ; DIFFERENTIATION ; MINERALIZATION ; NANOFIBERS ; VESICLES |
| 资助项目 | Chinese Major Program for National Key Research and Development Project[2020YFA0112603] ; Strategic Priority Research Program of the Chinese Academy of Science[XDA16020808] ; Beijing Municipal Natural Science Foundation[7212206] ; National Natural Science Foundation of China[22277121] ; National Natural Science Foundation of China[22072155] ; National Natural Science Foundation of China[22002170] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; Max-Planck Society |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000893031400001 |
| 出版者 | ELSEVIER |
| 资助机构 | Chinese Major Program for National Key Research and Development Project ; Strategic Priority Research Program of the Chinese Academy of Science ; Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; Max-Planck Society |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56108]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Bai, Shuo; Seeberger, Peter H.; Yin, Jian |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Max Planck Inst Colloids & Interfaces, Biomol Syst Dept, Muhlenberg 1, D-14476 Potsdam, Germany |
| 推荐引用方式 GB/T 7714 | Hao, Linna,Wang, Anhe,Fu, Junjie,et al. Biomineralized dipeptide self-assembled hydrogel with ultrahigh mechanical strength and osteoinductivity for bone regeneration[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2023,657:10. |
| APA | Hao, Linna.,Wang, Anhe.,Fu, Junjie.,Liang, Sen.,Han, Qingquan.,...&Yin, Jian.(2023).Biomineralized dipeptide self-assembled hydrogel with ultrahigh mechanical strength and osteoinductivity for bone regeneration.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,657,10. |
| MLA | Hao, Linna,et al."Biomineralized dipeptide self-assembled hydrogel with ultrahigh mechanical strength and osteoinductivity for bone regeneration".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 657(2023):10. |
入库方式： OAI收割
来源：过程工程研究所
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