Virus-like Particles for TEM Regulation and Antitumor Therapy
文献类型：期刊论文
| 作者 | Yang, Zhu1,2; Chi, Yongjie1,2; Bao, Jiaxin1,3; Zhao, Xin1,3; Zhang, Jing1,2; Wang, Lianyan1,2 |
| 刊名 | JOURNAL OF FUNCTIONAL BIOMATERIALS
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 13期号:4页码:13 |
| 关键词 | virus-like particle tumor microenvironment immunotherapy nanovaccine |
| DOI | 10.3390/jfb13040304 |
| 英文摘要 | Tumor development and metastasis are intimately associated with the tumor microenvironment (TME), and it is difficult for vector-restricted drugs to act on the TME for long-term cancer immunotherapy. Virus-like particles (VLPs) are nanocage structures self-assembled from nucleic acid free viral proteins. Most VLPs range from 20-200 nm in diameter and can naturally drain into lymph nodes to induce robust humoral immunity. As natural nucleic acid nanocarriers, their surfaces can also be genetically or chemically modified to achieve functions such as TME targeting. This review focuses on the design ideas of VLP as nanocarriers and the progress of their research in regulating TME. |
| WOS关键词 | TUMOR MICROENVIRONMENT ; CANCER-IMMUNOTHERAPY ; TARGETED DELIVERY ; DENDRITIC CELLS ; VACCINE ; NANOPARTICLES ; ANTIGEN ; IMMUNITY ; COMBINATION ; STATISTICS |
| 资助项目 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; [81973262] ; [82011530138] ; [81970660] ; [L202039] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000901318800001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56244]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Lianyan |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China 3.Heilongjiang Univ Tradit Chinese Med, Sch Pharm, Harbin 150040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhu,Chi, Yongjie,Bao, Jiaxin,et al. Virus-like Particles for TEM Regulation and Antitumor Therapy[J]. JOURNAL OF FUNCTIONAL BIOMATERIALS,2022,13(4):13. |
| APA | Yang, Zhu,Chi, Yongjie,Bao, Jiaxin,Zhao, Xin,Zhang, Jing,&Wang, Lianyan.(2022).Virus-like Particles for TEM Regulation and Antitumor Therapy.JOURNAL OF FUNCTIONAL BIOMATERIALS,13(4),13. |
| MLA | Yang, Zhu,et al."Virus-like Particles for TEM Regulation and Antitumor Therapy".JOURNAL OF FUNCTIONAL BIOMATERIALS 13.4(2022):13. |
入库方式： OAI收割
来源：过程工程研究所
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