Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization
文献类型：期刊论文
| 作者 | Ma, Yuqi1; Wang, Anhe1,2; Li, Jieling1,2; Li, Qi1,2; Han, Qingquan1,2; Jing, Yafeng1; Zheng, Xuefang3; Cao, Hongyu3; Yan, Xuehai1,2; Bai, Shuo1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2022-12-29 |
| 页码 | 12 |
| ISSN号 | 1944-8244 |
| 关键词 | peptide self-assembly CaCO3 particles surface modification cell internalization cancer therapy |
| DOI | 10.1021/acsami.2c21447 |
| 英文摘要 | The self-assembling behavior of peptides and derivatives is crucial in the natural process to construct various architectures and achieve specific functions. However, the surface or interfacial self assembly, in particular, on the surface of micro-or nanoparticles is even less systematically investigated. Here, uniform porous CaCO3 micro particles were prepared with different charged, hydrophobic and hydrophilic surfaces to assess the self-assembling behavior of dipeptides composed of various sequences. Experimental results indicate that dipeptides with a negative charge in an aqueous solution preferred to self-assemble on the hydrophobic and positively charged surface of CaCO3 particles, which can be ascribed to the electrostatic and hydrophobic interaction between dipeptides and CaCO3 particles. Meanwhile, the Log p (lipid-water partition coefficient) of dipeptides has a significant effect on the self-assembling behavior of dipeptides on the surface of porous CaCO3; dipeptides with high Log p preferred to self-assemble on the surface of CaCO3 particles, resulting in the improved cell internalization efficiency of particles with low cytotoxicity. After loading with a model drug (doxorubicin), the particles show obvious antitumor activity in animal experiments and can reduce Dox side effects effectively. |
| WOS关键词 | IN-VITRO ; PEPTIDE ; FABRICATION ; NANOPARTICLES ; ADSORPTION ; VESICLES ; DESIGN ; GOLD ; PH |
| 资助项目 | Chinese Major Program for National Key Research and Development Project[2020YFA0112603] ; Strategic Priority Research Program of the Chinese Academy of Science[XDA16020808] ; Beijing Municipal Natural Science Foundation[7212206] ; NationalNatural Science Foundation of China[22072155] ; NationalNatural Science Foundation of China[22002170] ; Project of Young Science and Technology Star of Dalian[2017RQ156] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000907016300001 |
| 资助机构 | Chinese Major Program for National Key Research and Development Project ; Strategic Priority Research Program of the Chinese Academy of Science ; Beijing Municipal Natural Science Foundation ; NationalNatural Science Foundation of China ; Project of Young Science and Technology Star of Dalian |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/56432]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Anhe; Cao, Hongyu; Bai, Shuo |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Univ, Coll Life Sci & Biotechnol, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Yuqi,Wang, Anhe,Li, Jieling,et al. Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization[J]. ACS APPLIED MATERIALS & INTERFACES,2022:12. |
| APA | Ma, Yuqi.,Wang, Anhe.,Li, Jieling.,Li, Qi.,Han, Qingquan.,...&Bai, Shuo.(2022).Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization.ACS APPLIED MATERIALS & INTERFACES,12. |
| MLA | Ma, Yuqi,et al."Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization".ACS APPLIED MATERIALS & INTERFACES (2022):12. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。