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Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction

文献类型：期刊论文

作者Li, Wang1,2,3; Shu, Xinyu1,2,3; Zhang, Xiaoyu1,2,3; Zhang, Ziliang2,3; Sun, Shujin1,2,3; Li, Ning1,2,3; Long, Mian1,2,3; Long M(龙勉); Sun SJ(孙树津); Li N(李宁)
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2023-02-01
卷号24期号:3页码:20
关键词microgravity liver metabolism mechanosensing cytoskeleton nuclear deformation phase separation
DOI10.3390/ijms24032197
通讯作者Li, Ning(lining_1@imech.ac.cn) ; Long, Mian(mlong@imech.ac.cn)
英文摘要Microgravity exposure during spaceflight causes the disordered regulation of liver function, presenting a specialized mechano-biological coupling process. While YAP/TAZ serves as a typical mechanosensitive pathway involved in hepatocyte metabolism, it remains unclear whether and how it is correlated with microgravity-induced liver dysfunction. Here, we discussed liver function alterations induced by spaceflight or simulated effects of microgravity on Earth. The roles of YAP/TAZ serving as a potential bridge in connecting liver metabolism with microgravity were specifically summarized. Existing evidence indicated that YAP/TAZ target gene expressions were affected by mechanotransductive pathways and phase separation, reasonably speculating that microgravity might regulate YAP/TAZ activation by disrupting these pathways via cytoskeletal remodeling or nuclear deformation, or disturbing condensates formation via diffusion limit, and then breaking liver homeostasis.
WOS关键词MESENCHYMAL STEM-CELLS ; INHIBITS OSTEOGENIC DIFFERENTIATION ; SIMULATED MICROGRAVITY ; PHASE-SEPARATION ; SPACE-FLIGHT ; 3-DIMENSIONAL CULTURE ; PROSTATE-CANCER ; GENE-EXPRESSION ; HIPPO PATHWAY ; IN-VITRO
资助项目National Key R&D Program of China[2021YFA0719300] ; National Natural Science Foundation of China[32130061] ; National Natural Science Foundation of China[32271366] ; Key Research Program of Chinese Academy of Sciences[ZDBS-ZRKJZ-TLC002]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000929572400001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Key Research Program of Chinese Academy of Sciences
源URL[http://dspace.imech.ac.cn/handle/311007/91688]  
专题力学研究所_国家微重力实验室
通讯作者Li, Ning; Long, Mian; Long M(龙勉); Li N(李宁)
作者单位1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing Key Lab Engn Construction & Mechanobiol, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Li, Wang,Shu, Xinyu,Zhang, Xiaoyu,et al. Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(3):20.
APA Li, Wang.,Shu, Xinyu.,Zhang, Xiaoyu.,Zhang, Ziliang.,Sun, Shujin.,...&Li W.(2023).Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(3),20.
MLA Li, Wang,et al."Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.3(2023):20.

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来源：力学研究所

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