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Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients

文献类型：期刊论文

作者Lui, Simon S. Y.5; Wang, Ling-ling3,4; Lau, Wilson Y. S.2; Shing, Eunice5; Yeung, Hera K. H.2; Tsang, Kirby C. M.2; Zhan, Emma N.5; Cheung, Ezmond S. L.5; Ho, Karen K. Y.2; Hung, Karen S. Y.5
刊名ASIAN JOURNAL OF PSYCHIATRY
出版日期2023-03-01
卷号81页码:7
ISSN号1876-2018
关键词Negative symptoms Emotion -behaviour decoupling Experiential pleasure Functional outcome Longitudinal
DOI10.1016/j.ajp.2023.103467
通讯作者Lui, Simon S. Y.(lsy570@hku.hk) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要Background: Emotion-behaviour decoupling refers to the failure to translate emotion into motivated behaviour, and is a putative marker for schizophrenia. The heterogeneity of experiential pleasure and emotion expressivity deficits has been reported in schizophrenia patients. These three constructs are believed to contribute to negative symptoms, but very few studies have examined their predictive ability for clinical and functional outcome of schizophrenia. This study aimed to clarify whether these three constructs influence clinical and functional outcome of schizophrenia.Method: At baseline, 127 first-episode schizophrenia patients completed a behavioural paradigm for emotion -behaviour decoupling, and self-report scales for experiential pleasure and emotion expressivity deficits. Cluster-analysis was applied to characterize schizophrenia subgroups based on these three constructs. At end-point (mean follow-up = 5.37 years, SD = 1.03 years), 85 schizophrenia patients were reassessed using the Clinical Assessment Interview for Negative Symptoms (CAINS) and a clinician-rated social functioning scale.Results: Cluster 1 (n = 74) did not show emotion-behaviour decoupling, and had intact experiential pleasure and emotion expressivity. Cluster 2 (n = 29) showed emotion-behaviour decoupling and experiential pleasure def-icits. Cluster 3 (n = 24) showed emotion expressivity deficits. At endpoint, the three clusters differed significantly in CAINS MAP factor (p = 0.016) and social functioning (p = 0.019), but not CAINS EXP factor. Specifically, Cluster 2 (n = 18) showed more severe negative symptoms of CAINS MAP factor (p = 0.046) and poorer social functioning (p = 0.022) than Cluster 1 (n = 49). Cluster 3 (n = 18) did not differ from Cluster 1 and Cluster 2 in negative symptoms and social functioning.Discussion: Emotion-behaviour decoupling and experiential pleasure deficits predicted clinical and functional outcome of schizophrenia.
收录类别SCI
WOS关键词SCALE ; ANHEDONIA ; RELIABILITY ; MOTIVATION ; IV
资助项目General Research Fund of Research Grant Council[17120622] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3415CX] ; Phillip K.H. Wong Foundation
WOS研究方向Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000924586500001
资助机构General Research Fund of Research Grant Council ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Phillip K.H. Wong Foundation
源URL[http://ir.psych.ac.cn/handle/311026/44721]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Lui, Simon S. Y.; Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Castle Peak Hosp, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
5.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Lui, Simon S. Y.,Wang, Ling-ling,Lau, Wilson Y. S.,et al. Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients[J]. ASIAN JOURNAL OF PSYCHIATRY,2023,81:7.
APA Lui, Simon S. Y..,Wang, Ling-ling.,Lau, Wilson Y. S..,Shing, Eunice.,Yeung, Hera K. H..,...&Chan, Raymond C. K..(2023).Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients.ASIAN JOURNAL OF PSYCHIATRY,81,7.
MLA Lui, Simon S. Y.,et al."Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients".ASIAN JOURNAL OF PSYCHIATRY 81(2023):7.

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来源：心理研究所

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