Duration of untreated illness and clinical correlates in first-episode and drug-na?ve patients with major depressive disorder
文献类型：期刊论文
| 作者 | Luo, Guoshuai3; Li, Yaxi2; Yao, Cong3; Li, Meijuan3; Li, Jie3 ; Zhang, Xiangyang1
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| 刊名 | PSYCHIATRY RESEARCH
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 320页码:8 |
| 关键词 | Major depressive disorder Duration of untreated illness Clinical correlates First-episode Drug-na?ve |
| ISSN号 | 0165-1781 |
| DOI | 10.1016/j.psychres.2023.115056 |
| 通讯作者 | Li, Jie(jieli@tmu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Backgrounds: The notion that a prolonged duration of untreated illness (DUI) leads to poorer outcomes has contributed to extensive changes in mental health services worldwide. However, most studies on DUI have focused on schizophrenia and related psychosis. This study aimed to assess the possible relationship between DUI and certain clinical correlates in first-episode and drug-naive patients with major depressive disorder (MDD).Methods: This cross-sectional study recruited 1718 first-episode and drug-naive MDD outpatients. All participants were scored on the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Positive and Negative Syndrome Scale, and thyroid hormone and metabolic parameters were measured. We used the Structure Clinical Interview for DSM-IV for clinical diagnosis and investigated suicide attempts through face-to-face interviews.Results: A total of 171 (10%) of MDD patients had co-morbid psychiatric symptoms. Participants who were older, with lower education level, and married were less likely to seek a timely treatment compared to the counterparts. One-month longer untreated duration was associated with 2% to 9% higher odds of being with most of the investigated clinical conditions. For those with the longest DUI, the risk was increased for most of the investi-gated clinical conditions, with absolute risk differences ranging from 5.19% to 29.48%.Conclusions: These findings suggest that longer DUI may be negatively associated with clinical correlates in MDD. Further long-term follow-up studies are warranted to confirm these preliminary results. |
| 收录类别 | SCI |
| WOS关键词 | METABOLIC SYNDROME ; MENTAL-DISORDERS ; SUICIDE ATTEMPTS ; NAIVE PATIENTS ; 1ST ONSET ; PSYCHOSIS ; ANXIETY ; SCHIZOPHRENIA ; SYMPTOMS ; DELAY |
| 资助项目 | National Natural Science Foundation of China[81973759] ; National Natural Science Foundation of China[81573905] ; National Key R&D Program of China[2020YFC2003100] ; National Key R&D Program of China[2020YFC2003103] ; Capital's Funds for Health Improvement and Research[SF2020-1-2011] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000924476900001 |
| 出版者 | ELSEVIER IRELAND LTD |
| 资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China ; Capital's Funds for Health Improvement and Research |
| 源URL | [http://ir.psych.ac.cn/handle/311026/44724]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li, Jie; Zhang, Xiangyang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 3210 Humin Rd, Shanghai 201108, Peoples R China 3.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Guoshuai,Li, Yaxi,Yao, Cong,et al. Duration of untreated illness and clinical correlates in first-episode and drug-na?ve patients with major depressive disorder[J]. PSYCHIATRY RESEARCH,2023,320:8. |
| APA | Luo, Guoshuai,Li, Yaxi,Yao, Cong,Li, Meijuan,Li, Jie,&Zhang, Xiangyang.(2023).Duration of untreated illness and clinical correlates in first-episode and drug-na?ve patients with major depressive disorder.PSYCHIATRY RESEARCH,320,8. |
| MLA | Luo, Guoshuai,et al."Duration of untreated illness and clinical correlates in first-episode and drug-na?ve patients with major depressive disorder".PSYCHIATRY RESEARCH 320(2023):8. |
入库方式： OAI收割
来源：心理研究所
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