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The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial

文献类型：期刊论文

作者Wei, Kai4; Bi, Yanzhi2,3; Xu, Huihong4; Shen, Ling4; Liu, Yantao4; Chen, Qianbo4; Miao, Xuerong4; Wu, Cheng1; Hu, Li2,3; Lu, Zhi-jie4
刊名PAIN PHYSICIAN
出版日期2022-12-01
卷号25期号:9页码:E1367-E1377
ISSN号1533-3159
关键词Men patients who smoke tramadol sufentanil postoperative pain management analgesic efficacy RCT analgesic consumption partial hepatectomy
通讯作者Lu, Zhi-jie(lzjwxyz@163.com)
英文摘要Background: Smoking behavior alters the analgesic threshold, which challenges postoperative pain management for patients who smoke.Objectives: We aimed to assess the analgesic efficacy of tramadol versus sufentanil in relieving postoperative pain for patients who do and do not smoke who underwent a partial hepatectomy.Study Design: Double-blinded randomized controlled trial.Setting: Eastern Hepatobiliary Surgery Hospital, Shanghai, China.Methods: All patients in this study were men. A total of 66 patients who smoke were randomly assigned to receive tramadol or sufentanil (n = 33 each). In addition, a total of 66 patients who do not smoke were randomly assigned to receive tramadol or sufentanil (n = 33 each). The primary outcome was the consumption of additional analgesics within the first 48 hours to control postoperative pain. Secondary outcomes included the postoperative pain level, the frequency of postoperative nausea and vomiting, the sedation score, and the frequency of fever within 48 hours postsurgery.Results: A significant interaction between "analgesic strategy " and "smoking history " was detected on the consumption of additional analgesics. In those who smoke, the requests for additional doses of analgesics were significantly less in those receiving tramadol than those receiving sufentanil; such a difference was not observed in those who do not smoke. The postoperative pain level was not significantly different between the tramadol group and the sufentanil group within patients who smoke within 48 hours postsurgery. The incidence of treatment-related adverse events was not significantly different between the tramadol group and the sufentanil group within both those who do and do not smoke.Limitations: Only men patients were included. Also, the superior analgesic effect and the incidence of adverse events of tramadol in patients who smoke were only assessed within the first 48 hours postsurgery.Conclusions: Our data suggest that tramadol has a better analgesic effect than sufentanil in relieving postoperative pain in patients who smoke.
收录类别SCI
WOS关键词TOBACCO SMOKING ; NICOTINE ; WITHDRAWAL ; REQUIREMENTS ; REWARD
资助项目Science and Technology Commission of Shanghai Municipality[17411960400] ; Shanghai Shen Kang Hospital Development Center[SHDC12018X19] ; National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[32071061] ; National Natural Science Foundation of China[31822025]
WOS研究方向Anesthesiology ; Neurosciences & Neurology
语种英语
出版者AM SOC INTERVENTIONAL PAIN PHYSICIANS
WOS记录号WOS:000918060600004
资助机构Science and Technology Commission of Shanghai Municipality ; Shanghai Shen Kang Hospital Development Center ; National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/44730]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Lu, Zhi-jie
作者单位1.Naval Med Univ, Dept Hlth Stat, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Shanghai Eastern Hepatobiliary Surg Hosp, Dept Anaesthesiol, Shanghai 200438, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Kai,Bi, Yanzhi,Xu, Huihong,et al. The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial[J]. PAIN PHYSICIAN,2022,25(9):E1367-E1377.
APA Wei, Kai.,Bi, Yanzhi.,Xu, Huihong.,Shen, Ling.,Liu, Yantao.,...&Lu, Zhi-jie.(2022).The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial.PAIN PHYSICIAN,25(9),E1367-E1377.
MLA Wei, Kai,et al."The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial".PAIN PHYSICIAN 25.9(2022):E1367-E1377.

入库方式： OAI收割

来源：心理研究所

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