Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis
文献类型：期刊论文
| 作者 | Li, Ning9; Ma, Wen8; Ren, Fuxin7,9; Li, Xiao7,9; Li, Fuyan7,9; Zong, Wei7,9; Wu, Lili6 ; Dai, Zongrui5; Hui, Steve C. N.3,4; Edden, Richard A. E.3,4
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| 刊名 | NEUROIMAGE
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| 出版日期 | 2023-03-01 |
| 卷号 | 268页码:14 |
| ISSN号 | 1053-8119 |
| 关键词 | Presbycusis Cognitive impairment Cognitive-ear link GABA Resting-state networks |
| DOI | 10.1016/j.neuroimage.2023.119861 |
| 通讯作者 | Gao, Fei(feigao@email.sdu.edu.cn) |
| 英文摘要 | Recent studies suggest that the interaction between presbycusis and cognitive impairment may be partially ex-plained by the cognitive-ear link. However, the underlying neurophysiological mechanisms remain largely un-known. In this study, we combined magnetic resonance spectroscopy (MRS) and resting-state functional magnetic resonance imaging (fMRI) to investigate auditory gamma-aminobutyric acid (GABA) and glutamate (Glu) levels, intra-and inter-network functional connectivity, and their relationships with auditory and cognitive function in 51 presbycusis patients and 51 well-matched healthy controls. Our results confirmed reorganization of the cognitive-ear link in presbycusis, including decreased auditory GABA and Glu levels and aberrant functional con-nectivity involving auditory networks (AN) and cognitive-related networks, which were associated with reduced speech perception or cognitive impairment. Moreover, mediation analyses revealed that decreased auditory GABA levels and dysconnectivity between the AN and default mode network (DMN) mediated the association between hearing loss and impaired information processing speed in presbycusis. These findings highlight the importance of AN-DMN dysconnectivity in cognitive-ear link reorganization leading to cognitive impairment, and hearing loss may drive reorganization via decreased auditory GABA levels. Modulation of GABA neurotransmission may lead to new treatment strategies for cognitive impairment in presbycusis patients. |
| 收录类别 | SCI |
| WOS关键词 | HEARING-LOSS ; HUMAN BRAIN ; AUDITORY-CORTEX ; IN-VIVO ; RELAXATION-TIMES ; CINGULATE CORTEX ; OLDER-ADULTS ; GABA ; SPEECH ; NETWORK |
| 资助项目 | National Natural Science Foundation of China for Young Scholars[81601479] ; Taishan Scholars Project[tsqn201812147] ; Shandong Provincial Natural Science Foundation of China[ZR2021MH030] ; Shandong Provincial Natural Science Foundation of China[ZR2021MH355] ; Jinan Science and Technology Development Program of China[202019098] ; Academic Promotion Programme of Shandong First Medical University[2019QL023] ; NIH[R01 EB016089] ; NIH[R01 EB023963] ; NIH[R21 AG060245] ; NIH[P41 EB015909] ; NIH[P41 EB031771] |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000925221300001 |
| 资助机构 | National Natural Science Foundation of China for Young Scholars ; Taishan Scholars Project ; Shandong Provincial Natural Science Foundation of China ; Jinan Science and Technology Development Program of China ; Academic Promotion Programme of Shandong First Medical University ; NIH |
| 源URL | [http://ir.psych.ac.cn/handle/311026/44744]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Gao, Fei |
| 作者单位 | 1.Shandong First Med Univ, Dept Radiol, Shandong Prov Hosp, Jing wu Rd 324, Jinan 250021, Peoples R China 2.Vanderbilt Univ, Inst Imaging Sci, Nashville, TN USA 3.Kennedy Krieger Inst, F M Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA 4.Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD USA 5.Southwest Univ, Westa Coll, Chongqing, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 7.Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Radiol, Jinan, Peoples R China 8.Shandong Univ, Cent Hosp Jinan City, Cheeloo Coll Med, Dept Otolaryngol, Jinan, Peoples R China 9.Shandong First Med Univ, Dept Radiol, Shandong Prov Hosp, Jinan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Ma, Wen,Ren, Fuxin,et al. Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis[J]. NEUROIMAGE,2023,268:14. |
| APA | Li, Ning.,Ma, Wen.,Ren, Fuxin.,Li, Xiao.,Li, Fuyan.,...&Gao, Fei.(2023).Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis.NEUROIMAGE,268,14. |
| MLA | Li, Ning,et al."Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis".NEUROIMAGE 268(2023):14. |
入库方式： OAI收割
来源：心理研究所
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