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Prevalence and correlates of dyslipidemia in first-episode and drug-naive major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences

文献类型：期刊论文

作者Zhu, Quanfeng4,5; Zheng, Yali4; Lang, XiaoE3; Fu, Zhengchuang4; Zhang, Peng4; Jiang, Guojun4; Zhang, Xiangyang1,2
刊名FRONTIERS IN PSYCHIATRY
出版日期2023-01-30
卷号14页码:8
关键词major depressive disorder dysglycemia dyslipidemia first-episode drug-naive
ISSN号1664-0640
DOI10.3389/fpsyt.2023.1101865
通讯作者Jiang, Guojun(jguojun999@hznu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要BackgroundLipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, the frequency and risk factors of dyslipidemia in first-episode and drug-naive (FEDN) MDD patients with dysglycemia were examined according to sex. MethodsOne thousand seven hundred and eighteen FEDN MDD patients were recruited and their demographic data, clinical data, various biochemical indicators and scale assessment scores including 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were collected. ResultsThe prevalence of abnormal lipid metabolism in both male and female MDD patients with abnormal glucose metabolism was higher than that in patients without abnormal glucose metabolism. Among male MDD patients with abnormal glucose metabolism, TC was positively correlated with HAMD score, TSH and TgAb levels, but negatively correlated with PANSS positive subscale scores. LDL-C was positively correlated with TSH and BMI, but negatively correlated with PANSS positive subscale scores. HDL-C was negatively correlated with TSH levels. Among females, TC was positively correlated with HAMD score, TSH, and BMI, but negatively correlated with PANSS positive subscale score. LDL-C was positively correlated with HADM score and negatively correlated with FT3 level. HDL-C was negatively correlated with TSH and BMI levels. ConclusionThere are sex differences in the correlated factors of lipid markers in MDD patients with impaired glucose.
收录类别SCI
WOS关键词GENDER-DIFFERENCES ; LIPID-METABOLISM ; ASSOCIATION ; ANXIETY
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000931106900001
出版者FRONTIERS MEDIA SA
源URL[http://ir.psych.ac.cn/handle/311026/44753]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Jiang, Guojun; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Shanxi Med Univ, Hosp 1, Med Coll, Dept Psychiat,Clin 1, Taiyuan, Peoples R China
4.Hangzhou Normal Univ, Affiliated Xiaoshan Hosp, Hangzhou, Peoples R China
5.Zhejiang Chinese Med Univ, Grad Sch, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Quanfeng,Zheng, Yali,Lang, XiaoE,et al. Prevalence and correlates of dyslipidemia in first-episode and drug-naive major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences[J]. FRONTIERS IN PSYCHIATRY,2023,14:8.
APA Zhu, Quanfeng.,Zheng, Yali.,Lang, XiaoE.,Fu, Zhengchuang.,Zhang, Peng.,...&Zhang, Xiangyang.(2023).Prevalence and correlates of dyslipidemia in first-episode and drug-naive major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences.FRONTIERS IN PSYCHIATRY,14,8.
MLA Zhu, Quanfeng,et al."Prevalence and correlates of dyslipidemia in first-episode and drug-naive major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences".FRONTIERS IN PSYCHIATRY 14(2023):8.

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来源：心理研究所

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