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The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naive schizophrenia

文献类型：期刊论文

作者Shen, Haoran2,4; Ge, Likun2,4; Cao, Bo1; Wei, Gao-Xia2,4; Zhang, Xiangyang2,3
刊名INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
出版日期2023-07-01
卷号23期号:3页码:7
ISSN号1697-2600
关键词Schizophrenia Depression Treatment Rostral anterior cingulate cortex
DOI10.1016/j.ijchp.2023.100372
通讯作者Wei, Gao-Xia(weigx@psych.ac.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: Our previous study has shown the cingulate cortex abnormalities in first-episode drug naive (FEDN) schizophrenia patients with comorbid depressive symptoms. However, it remains largely unknown whether anti -psychotics may induce morphometric change in cingulate cortex and its relationship with depressive symptoms. The purpose of this study was to further clarify the important role of cingulate cortex in the treatment on depres-sive symptoms in FEDN schizophrenia patients.Method: In this study, 42 FEDN schizophrenia patients were assigned into depressed patients group (DP, n = 24) and non-depressed patients group (NDP, n = 18) measured by the 24-item Hamilton Depression Rating Scale (HAMD). Clinical assessments and anatomical images were obtained from all patients before and after 12-week treatment with risperidone.Results: Although risperidone alleviated psychotic symptoms in all patients, depressive symptoms were decreased only in DP. Significant group by time interaction effects were found in the right rostral anterior cingulate cortex (rACC) and other subcortical regions in the left hemisphere. After risperidone treatment, the right rACC were increased in DP. Further, the increasing volume of right rACC was negatively associated with improvement in depressive symptoms.Conclusion: These findings suggested that the abnormality of the rACC is the typical characteristics in schizophre-nia with depressive symptoms. It's likely key region contributing to the neural mechanisms underlying the effects of risperidone treatment on depressive symptoms in schizophrenia.
收录类别SCI
WOS关键词BRAIN ; RISPERIDONE ; ANTERIOR ; SCALE ; MRI ; SEROTONIN ; VOLUME
资助项目National Natural Science Foundation of China[31671163] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3815CX]
WOS研究方向Psychology
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000926553400001
资助机构National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/44762]  
专题心理研究所_中国科学院心理健康重点实验室
心理研究所_中国科学院行为科学重点实验室
通讯作者Wei, Gao-Xia; Zhang, Xiangyang
作者单位1.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Haoran,Ge, Likun,Cao, Bo,et al. The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naive schizophrenia[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2023,23(3):7.
APA Shen, Haoran,Ge, Likun,Cao, Bo,Wei, Gao-Xia,&Zhang, Xiangyang.(2023).The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naive schizophrenia.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,23(3),7.
MLA Shen, Haoran,et al."The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naive schizophrenia".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 23.3(2023):7.

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来源：心理研究所

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