4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation in vitro
文献类型：期刊论文
| 作者 | Sun, Zhendong; Cao, Huiming; Liu, Qian S.; Liang, Yong; Fiedler, Heidelore; Zhang, Jianqing; Zhou, Qunfang; Jiang, Guibin
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| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2021 |
| 卷号 | 268页码:- |
| 关键词 | Obesity Estrogen receptor Nonalcoholic fatty liver disease Adipogenesis Lipogenesis |
| ISSN号 | 0269-7491 |
| 英文摘要 | Finding the potential environmental obesogens is crucial to explain the prevalence of obesity and the related pathologies. Increasing evidence has showed that many chemicals with endocrine disrupting effects can disturb lipid metabolism. Whether 4-hexylphenol (4-HP), a widely-used surfactant and a potential endocrine disrupting chemical (EDC), is associated to influence adipogenesis and hepatic lipid accumulation remained to be elucidated. In this study, both the 3T3-L1 differentiation model and oleic acid (OA)-treated HepG2 cells were used to investigate the effects of 4-HP on lipid metabolism, and the underlying estrogen receptor (ER)-involved mechanism was explored using MVLN assay, molecular docking simulation and the antagonist test. The results based on lipid droplet staining and triglyceride accumulation assay showed that 4-HP treatment promoted the adipogenic differentiation of 3T3-L1 cells and increased hepatic cellular OA accumulation in exposure concentration-dependent manners. The study on the elaborated transcription networks indicated that 4-HP activated peroxisome proliferator-activated receptor gamma (PPAR gamma) as well as the subsequent adipogenic gene program in 3T3-L1 cells. This chemical also induced the increase of OA uptake and decreases of de novo lipogenesis and fatty acid oxidation in HepG2 cells. The agonistic activity of 4-HP in triggering ER-mediated pathway was shown to correlate with its perturbation in lipid metabolism, as evidenced by the enhanced development of mature lipid-laden adipocytes and suppression of excessive hepatic lipid accumulation upon its co-treatment with ER antagonist. Altogether, these findings provide new insights into the potential health impacts of 4-HP exposure as it may relate to obesity and nonalcoholic fatty liver disease. (C) 2020 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45635]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 4.Orebro Univ, MTM Res Ctr, Sch Sci & Technol, SE-70182 Orebro, Sweden 5.Shenzhen Ctr Dis Control & Prevent, POPs Lab, Shenzhen 518055, Peoples R China 6.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R |
| 推荐引用方式 GB/T 7714 | Sun, Zhendong,Cao, Huiming,Liu, Qian S.,et al. 4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation in vitro[J]. ENVIRONMENTAL POLLUTION,2021,268:-. |
| APA | Sun, Zhendong.,Cao, Huiming.,Liu, Qian S..,Liang, Yong.,Fiedler, Heidelore.,...&Jiang, Guibin.(2021).4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation in vitro.ENVIRONMENTAL POLLUTION,268,-. |
| MLA | Sun, Zhendong,et al."4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation in vitro".ENVIRONMENTAL POLLUTION 268(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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