A case-control study on the association of mineral elements exposure and thyroid tumor and goiter
文献类型：期刊论文
| 作者 | Liu, Mei; Song, Jiayi; Jiang, Yousheng; Liu, Yuan; Peng, Jinling; Liang, Huiwen; Wang, Chao ; Jiang, Jie; Liu, Xinjie; Wei, Wei
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2021-01-15 |
| 卷号 | 208页码:- |
| 关键词 | Mineral elements Thyroid tumor and goiter Thyroid function Association Case-control study |
| ISSN号 | 0147-6513 |
| 英文摘要 | Thyroid tumor and thyroid goiter are prevalent disease around the world. In this case-control study, we investigated the association between exposure to a total of twelve mineral elements and thyroid disease as well as thyroid functions. Participants with thyroid tumor or goiter (N = 197) were matched with a healthy population (N = 197) by age (+/- 2 years old) and same sex. Questionnaires were used to collect data about the demographic characteristics and information of subjects. Serum and urine samples were collected simultaneously for each of the subjects. Mineral elements, iodine level of urine and levels of the total seven thyroid function indexes in serum were detected respectively. Conditional logistic regression was applied to estimate the associations between mineral elements and the risk of thyroid tumor and goiter through single-element models and multiple element models. Multiple linear regression was used to evaluate relationships between mineral elements and percentage changes of thyroid functions. Higher concentrations of mineral elements in the recruited population were found in this study than other comparable studies, and the levels of chromium (Cr), manganese (Mn), nickel (Ni), arsenic (As), cadmium (Cd), selenium (Se), antimony (Sb), thallium (Tl) and lead (Pb) in the case group were lower than the control group. According to the single-element models, Cr, Mn, Ni, Sb and Tl showed significant negative associations with the risk of thyroid tumor and goiter, and, Cd showed nonmonotonic dose response. Cd and mercury (Hg) showed a nonmonotonic percentage change with T4, while Tl was associated with the increased FT4 in the control group. Therefore, Cd, Hg and Tl may disturb the balance of thyroid function to some extent, and Cr, Mn, Ni, Cd, Sb, and Tl may become potential influencing factors for the risk of thyroid tumor and goiter. |
| WOS研究方向 | Environmental Sciences ; Toxicology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45637]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Guangdong, Peoples R China 4.Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China 5.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China 6.Shenzhen Ctr Chron Dis Control, Shenzhen 518020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Mei,Song, Jiayi,Jiang, Yousheng,et al. A case-control study on the association of mineral elements exposure and thyroid tumor and goiter[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,208:-. |
| APA | Liu, Mei.,Song, Jiayi.,Jiang, Yousheng.,Liu, Yuan.,Peng, Jinling.,...&Zhang, Jianqing.(2021).A case-control study on the association of mineral elements exposure and thyroid tumor and goiter.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,208,-. |
| MLA | Liu, Mei,et al."A case-control study on the association of mineral elements exposure and thyroid tumor and goiter".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 208(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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