A feasible strategy to improve confident elemental composition determination of compounds in complex organic mixture such as natural organic matter by FTICR-MS without internal calibration
文献类型：期刊论文
| 作者 | Cao, Dong ; Hao, Zhineng; Hu, Ming; Geng, Fanglan; Rao, Ziyu; Niu, Hongyun; Shi, Yali; Cai, Yaqi; Zhou, Yiqi; Liu, Jingfu
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2021-01-10 |
| 卷号 | 751页码:- |
| ISSN号 | 0048-9697 |
| 关键词 | Spectral accuracy Mass accuracy FTICR-MS Complex organic mixture Natural organic matter |
| 英文摘要 | Confident elemental composition determination of compounds in complex samples such as natural organic matter (NOM) by ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is challenging due to the interference between multiple components in these samples during detection. Here the performance of Solarix 15T-FTICR-MS in terms of accurate relative natural isotope abundance (RIA) and mass measurements for elemental composition determination of compounds in complex samples such as NOM was systematically evaluated. The optimal sweep excitation power values ranging from 20% to 22% was found to significantly diminish the underestimation of RIA measurement for C-13(1) peaks of NOM components by FTICR-MS. Random error was found to be one of the main sources for the RIA errors of C-13(1) peaks with S/N ratios <25. The mean averaged RIA errors of less than 10% could be obtained by averaging the measured RIAs of each C-13(1) peaks in five replicated runs. By adjusting the total ion abundance of NOM complex sample between 3.8-E7 and 1.4-E8 which was simultaneously similar to that of external calibrant during detection, mass errors of lower than 1 ppm for NOM components with m/z lower than 700 Da could be obtained without internal calibration. Meanwhile, a linear correlation between mass errors of ions in NOM complex sample and their m/z values could be obtained. The mass error deviation derived from the linearity was firstly used as new criterion to reduce the number of false formula candidates. A novel strategy of combination of high mass accuracy, high spectral accuracy, and mass error deviation for elemental composition determination of unknown compounds in complex sample such as NOM by FTICR-MS was proposed and applied for different complex samples. Compared to the traditional method, about one fold increasement in the number of the unique formula assignments for measured ions was obtained by using our strategy. (C) 2020 Published by Elsevier B.V. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45638]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, PoB 2871,18 Shuangqing Rd, Beijing 100085, Peoples R China 2.Navy Gen Hosp, Cent Lab, 6 Fucheng Rd, Beijing 100048, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Dong,Hao, Zhineng,Hu, Ming,et al. A feasible strategy to improve confident elemental composition determination of compounds in complex organic mixture such as natural organic matter by FTICR-MS without internal calibration[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,751:-. |
| APA | Cao, Dong.,Hao, Zhineng.,Hu, Ming.,Geng, Fanglan.,Rao, Ziyu.,...&Kang, Yuehui.(2021).A feasible strategy to improve confident elemental composition determination of compounds in complex organic mixture such as natural organic matter by FTICR-MS without internal calibration.SCIENCE OF THE TOTAL ENVIRONMENT,751,-. |
| MLA | Cao, Dong,et al."A feasible strategy to improve confident elemental composition determination of compounds in complex organic mixture such as natural organic matter by FTICR-MS without internal calibration".SCIENCE OF THE TOTAL ENVIRONMENT 751(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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