A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness
文献类型：期刊论文
| 作者 | Lee, Myeongsang; Ni, Nengyi; Tang, Huayuan; Li, Yuhuan; Wei, Wei ; Kakinen, Aleksandr; Wan, Xulin; Davis, Thomas P.; Song, Yang; Leong, David Tai
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| 刊名 | ADVANCED SCIENCE
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| 页码 | - |
| 关键词 | discrete molecular dynamics simulation endothelial leakiness signaling pathway transwell VE cadherin |
| 英文摘要 | Nanomaterial-induced endothelial leakiness (NanoEL) is an interfacial phenomenon denoting the paracellular transport of nanoparticles that is pertinent to nanotoxicology, nanomedicine and biomedical engineering. While the NanoEL phenomenon is complementary to the enhanced permeability and retention effect in terms of their common applicability to delineating the permeability and behavior of nanoparticles in tumoral environments, these two effects significantly differ in scope, origin, and manifestation. In the current study, the descriptors are fully examined of the NanoEL phenomenon elicited by generic citrate-coated gold nanoparticles (AuNPs) of changing size and concentration, from microscopic gap formation and actin reorganization down to molecular signaling pathways and nanoscale interactions of AuNPs with VE-cadherin and its intra/extracellular cofactors. Employing synergistic in silico methodologies, for the first time the molecular and statistical mechanics of cadherin pair disruption, especially in response to AuNPs of the smallest size and highest concentration are revealed. This study marks a major advancement toward establishing a comprehensive NanoEL framework for complementing the understanding of the transcytotic pathway and for guiding the design and application of future nanomedicines harnessing the myriad functions of the mammalian vasculature. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45639]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA 2.Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore 3.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Key Lab Carcinogenesis & Canc Invas,Minist Educ, Shanghai 200032, Peoples R China 4.Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, 381 Royal Parade, Parkville, Vic 3052, Austra 5.Southwest Univ, Coll Pharmaceut Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, 2 Tiansheng Rd, Chongqing 400715, Peoples R China 6.Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Lee, Myeongsang,Ni, Nengyi,Tang, Huayuan,et al. A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness[J]. ADVANCED SCIENCE:-. |
| APA | Lee, Myeongsang.,Ni, Nengyi.,Tang, Huayuan.,Li, Yuhuan.,Wei, Wei.,...&Ke, Pu Chun. |
| MLA | Lee, Myeongsang,et al."A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness".ADVANCED SCIENCE |
入库方式： OAI收割
来源：生态环境研究中心
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