A strategy to differentiate dopamine and levodopa based on their cyclization reaction regulated by pH
文献类型：期刊论文
| 作者 | Wang, Yaotian; Zhang, Haiyan; Chen, Mingli |
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2021-05-01 |
| 卷号 | 1157页码:- |
| 关键词 | Catecholamines Dopamine Levodopa Cyclization reaction Differentiation Electrochemistry |
| ISSN号 | 0003-2670 |
| 英文摘要 | Levodopa is often used to treat Parkinson?s disease. It coexists with dopamine in human fluids and is electrochemically oxidized at the same potential as dopamine. Differentiating levodopa from dopamine is difficult via electrochemical techniques. Taking advantage of the differences in the rate constants of levodopa and dopamine for the intramolecular cyclization reaction, we observed that the cyclization reaction of dopamine-quinone was completely suppressed under pH 4.8, while that of levodopa-quinone occurred. The product of cyclization caused a new cathodic peak at negative potential. Its peak current was dependent on the concentration of levodopa but not that of dopamine. As a result, we developed a method of detecting levodopa in the presence of dopamine with a bare glassy carbon electrode. Levodopa is often used to treat Parkinson?s disease. It coexists with dopamine in human fluids and is electrochemically oxidized at the same potential as dopamine. Differentiating levodopa from dopamine is difficult via electrochemical techniques. Taking advantage of the differences in the rate constants of levodopa and dopamine for the intramolecular cyclization reaction, we observed that the cyclization reaction of dopamine-quinone was completely suppressed under pH 4.8, while that of levodopa-quinone occurred. The product of cyclization caused a new cathodic peak at negative potential. Its peak current was dependent on the concentration of levodopa but not that of dopamine. As a result, we developed a method of detecting levodopa in the presence of dopamine with a bare glassy carbon electrode. ? 2021 Elsevier B.V. All rights reserved. |
| WOS研究方向 | Chemistry, Analytical |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45641]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Northeastern Univ, Coll Sci, Dept Chem, Shenyang 110819, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yaotian,Zhang, Haiyan,Chen, Mingli. A strategy to differentiate dopamine and levodopa based on their cyclization reaction regulated by pH[J]. ANALYTICA CHIMICA ACTA,2021,1157:-. |
| APA | Wang, Yaotian,Zhang, Haiyan,&Chen, Mingli.(2021).A strategy to differentiate dopamine and levodopa based on their cyclization reaction regulated by pH.ANALYTICA CHIMICA ACTA,1157,-. |
| MLA | Wang, Yaotian,et al."A strategy to differentiate dopamine and levodopa based on their cyclization reaction regulated by pH".ANALYTICA CHIMICA ACTA 1157(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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