A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage
文献类型：期刊论文
| 作者 | Tao, Xiaoqi; Wan, Xulin; Wu, Di; Song, Erqun; Song, Yang |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-06-05 |
| 卷号 | 411页码:- |
| 关键词 | Copper oxide nanoparticles Reactive oxygen species Lysosomal damage Cathepsin B NLRP3 inflammasome |
| ISSN号 | 0304-3894 |
| 英文摘要 | For the first time, we reported that CuONPs exposure induced interleukin (IL)- 1?-mediated inflammation via NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome in J774A.1 macrophage. Mechanistically, CuONPs activated NLRP3 inflammasome is a two-fold process. Firstly, CuONPs challenge caused lysosomal damage, along with the release of cathepsin B, which directly mediated the activation of NLRP3 inflammasomes. Interestingly, after the deposition in lysosomes, CuONPs may release copper ion due to the acidic environment of lysosomes. Consequently, the released copper ions significantly induced cellular oxidative stress and further mediated the activation of NLRP3 inflammasomes. Moreover, CuONPs exposure could prime J774A.1 macrophage to express pro-IL-1? through myeloid differentiation factor 88 (MyD88)-dependent Tolllike receptor 4 (TLR4) signal pathway subsequently activating nuclear transcription factor kappa B (NF-?B). |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45644]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Southwest Univ, Coll Food Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China 2.Southwest Univ, Coll Pharmaceut Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, 2 Tiansheng Rd, Chongqing 400715, Peoples R Chi 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tao, Xiaoqi,Wan, Xulin,Wu, Di,et al. A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,411:-. |
| APA | Tao, Xiaoqi,Wan, Xulin,Wu, Di,Song, Erqun,&Song, Yang.(2021).A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage.JOURNAL OF HAZARDOUS MATERIALS,411,-. |
| MLA | Tao, Xiaoqi,et al."A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage".JOURNAL OF HAZARDOUS MATERIALS 411(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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