Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy
文献类型：期刊论文
| 作者 | Zhao, Chao; Xie, Peisi; Yong, Ting; Huang, Wei; Liu, Jianjun; Wu, Desheng; Ji, Fenfen; Li, Min; Zhang, Doudou; Li, Ruijin |
| 刊名 | SCIENCE BULLETIN
 |
| 出版日期 | 2021-03-30 |
| 卷号 | 66期号:6页码:578-591 |
| 关键词 | Airborne fine particulate matter Gestational exposure Lipid metabolism Mass spectrometry imaging Cognitive and emotional disorders |
| ISSN号 | 2095-9273 |
| 英文摘要 | Gestational exposure to PM2.5 is associated with adverse postnatal outcomes. PM2.5 can enter alveoli by using intratracheal instillation, even penetrate through lung cells into the blood circulation. Subsequently, they are transferred across the placenta and fetal blood brain barrier, causing the adverse birth outcomes of offspring. This study demonstrated that the gestational exposure resulted in cognitive and emotional disorders in female offspring although the offspring were not exposed to PM2.5. Placental metabolic pathways modulated fetal brain development and played a pivotal role for maternal-placental fetal interactions in the fetal programming of adult behavioral and mental disorders. Samples of fetus, offspring hippocampus and placenta from the mice exposed to PM2.5 were investigated using a comprehensive approach including mass spectrometry-based lipidomics and three-dimensional imaging. The exposure induced the neuro-degeneration in hippocampus, impairment of placental cytoarchitecture, and reprogramming of lipidome, which might affect the modulation of maternal-fetal cross-talk and result in the behavior disorders of offspring. The variation of spatial distribution of lipids was profoundly affected in dorsal pallium and hippocampal formation regions of fetal brain, offspring hippocampus, as well as labyrinth and junctional zones of placenta. The abundance alteration of lipid markers associated with neurodegenerative diseases was validated in transgenic mouse model with Alzheimer's disease and human cerebrospinal fluid from patients with Parkinson's disease. The finding could help with the selection of more suitable heterogeneous-related substructures targeting PM2.5 exposure and the exploration of PM2.5-induced toxicological effects on neurodegenerative diseases. (C) 2020 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
| WOS研究方向 | Multidisciplinary Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45651]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong 999077, Peoples R China 2.Shenzhen Ctr Dis Control & Prevent, Key Lab Modern Toxicol Shenzhen, Shenzhen 518000, Peoples R China 3.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China 4.Shenzhen Univ, Dept Funct Neurol & Neurosurg, Shenzhen Peoples Hosp 2, Affiliated Hosp 1,Sch Med, Shenzhen 518000, Peo 5.Shanxi Univ, Inst Environm Sci, Taiyuan 030000, Peoples R China 6.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Bei |
| 推荐引用方式 GB/T 7714 | Zhao, Chao,Xie, Peisi,Yong, Ting,et al. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy[J]. SCIENCE BULLETIN,2021,66(6):578-591. |
| APA | Zhao, Chao.,Xie, Peisi.,Yong, Ting.,Huang, Wei.,Liu, Jianjun.,...&Cai, Zongwei.(2021).Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy.SCIENCE BULLETIN,66(6),578-591. |
| MLA | Zhao, Chao,et al."Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy".SCIENCE BULLETIN 66.6(2021):578-591. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。