Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure
文献类型：期刊论文
| 作者 | Gao, Jie; Wang, Shunhao; Tang, Gang; Wang, Ziniu; Ma, Junjie; Wang, Yuanyuan; Liu, Yaquan; Guo, Hao; Li, Junya; Lv, Meilin |
| 刊名 | MATERIALS & DESIGN
 |
| 出版日期 | 2021-08 |
| 卷号 | 206页码:- |
| 关键词 | Graphene oxide In vivo Alterations of platelets Disturbance of splenic hematopoiesis |
| ISSN号 | 0264-1275 |
| 英文摘要 | In this study, we comprehensively explored graphene oxide (GO)-induced systemic immune responses and interference with hematopoiesis in mice upon GO intravenous injection. In the liver and spleen, GO led to alterations in immune components at different time points. GO exposure showed an effect on the populations of different types of hepatic macrophages. In the liver, the populations of macrophages mainly affected by GO including Kupffer cells and monocyte-derived macrophages. Stimulated hepatic inflammation led to the infiltration of platelets from the circulation into the liver and decreased peripheral platelets population at day 1. Interestingly, a decreased platelet population was observed on day 7 in the spleen. GO also led to accelerated hematopoiesis in the spleen. Therefore, the possible forced generation of more platelets and the release of mature platelets from the spleen contributed to the increased circulating platelet count on day 7. Therefore, although GO showed a low potential to induce severe inflammation in the liver and spleen, it disrupted hematopoiesis in the spleen, which contributed to fluctuations in circulating platelet counts. The interaction of GO with the immune system warrants comprehensive study for gaining better understanding.& nbsp; (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS研究方向 | Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45654]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Northeastern Univ, Coll Sci, Res Ctr Analyt Sci, Dept Chem, Shenyang 110819, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Jie,Wang, Shunhao,Tang, Gang,et al. Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure[J]. MATERIALS & DESIGN,2021,206:-. |
| APA | Gao, Jie.,Wang, Shunhao.,Tang, Gang.,Wang, Ziniu.,Ma, Junjie.,...&Jiang, Guibin.(2021).Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure.MATERIALS & DESIGN,206,-. |
| MLA | Gao, Jie,et al."Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure".MATERIALS & DESIGN 206(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。