Bacteria-Targeted MRI Probe-Based Imaging Bacterial Infection and Monitoring Antimicrobial Therapy In Vivo
文献类型：期刊论文
| 作者 | Li, Linyao; Gu, Peilin; Hao, Mengqi; Xiang, Xiaoli; Feng, Yuting; Zhu, Xiaokang; Song, Yang; Song, Erqun |
| 刊名 | SMALL
 |
| 页码 | - |
| 关键词 | bacterial infection imaging in vivo monitoring MRI probe |
| ISSN号 | 1613-6810 |
| 英文摘要 | Despite the significant advances of imaging techniques nowadays, accurate diagnosis of bacterial infections and real-time monitoring the efficacy of antibiotic therapy in vivo still remain huge challenges. Herein, a self-assembling peptide (FFYEGK) and vancomycin (Van) antibiotic molecule co-modified gadolinium (Gd) MRI nanoaggregate probe (GFV) for detecting Staphylococcus aureus (S. aureus) infection in vivo and monitoring the treatment of S. aureus-infected myositis by using daptomycin (Dap) antibiotic as model are designed and fabricated. The as-prepared GFV probe bears Van molecules, making itself good bacteria-specific targeting, and the peptide in the probe can enhance the longitudinal relaxivity rate (r(1)) after self-assembly due to the pi-pi stacking. The study showed that, based on the GFV probe, bacterial infections and sterile inflammation can be discriminated, and as few as 10(5) cfu S. aureus can be detected in vivo with high specificity and accurately. Moreover, the T-1 signal of GFV probe at the S. aureus-infected site in mice correlates with the increasing time of Dap treating, indicating the possibility of monitoring the efficacy of antibacterial agents for infected mice based on the as proposed GFV probe. This study shows the potential of GFV probe for diagnosis, evaluation, and prognosis of infectious diseases in clinics. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45666]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Linyao,Gu, Peilin,Hao, Mengqi,et al. Bacteria-Targeted MRI Probe-Based Imaging Bacterial Infection and Monitoring Antimicrobial Therapy In Vivo[J]. SMALL:-. |
| APA | Li, Linyao.,Gu, Peilin.,Hao, Mengqi.,Xiang, Xiaoli.,Feng, Yuting.,...&Song, Erqun. |
| MLA | Li, Linyao,et al."Bacteria-Targeted MRI Probe-Based Imaging Bacterial Infection and Monitoring Antimicrobial Therapy In Vivo".SMALL |
入库方式： OAI收割
来源：生态环境研究中心
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