Binding of Benzo[a]pyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy
文献类型：期刊论文
| 作者 | Ma, Juan; Liu, Xinlei; Yang, Yi; Qiu, Jiahuang; Dong, Zheng; Ren, Quanzhong; Zuo, Yi Y.; Xia, Tian; Chen, Wei; Liu, Sijin |
| 刊名 | ACS NANO
 |
| 出版日期 | 2021-06-22 |
| 卷号 | 15期号:6页码:9717-9731 |
| 关键词 | natural nanoparticles fine biochar particles benzo[a]pyrene adsorption bioreactivity macrophages |
| ISSN号 | 1936-0851 |
| 英文摘要 | Contaminant-bearing fine biochar particles (FBPs may exert significantly different toxicity profiles from their contaminant-free counterparts. While the role of FBPs in promoting contaminant uptake has been recognized, it is unclear whether the binding of contaminants can modify the biochemical reactivity and toxicological profiles of FBPs. Here, we show that binding of benzo[a]pyrene (B(a)P, a model polycyclic aromatic hydrocarbon) at environmentally relevant exposure concentrations markedly alters the cytotoxicity of FBPs to macrophages, an important line of innate immune defense against airborne particulate matters (PMs). Specifically, B(a)P-bearing FBPs elicit more severe disruption of the phospholipid membrane, endocytosis, oxidative stress, autophagy, and compromised innate immune defense, as evidenced by blunted proinflammatory effects, compared with B(a)P-free FBPs. Notably, the altered cytotoxicity cannot be attributed to the dissolution of B(a)P from the B(a)P-bearing FBPs, but appears to be related to B(a)P adsorption-induced changes of FBPs bioreactivity toward macrophages. Our findings highlight the significance of environmental chemical transformation in altering the bioreactivity and toxicity of PMs and call for further studies on other types of carbonaceous nanoparticles and additional exposure scenarios. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45668]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA 2.Univ Calif Los Angeles, Div NanoMed, Dept Med, Los Angeles, CA 90095 USA 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Univ Chinese Acad Sci, Sch Environm Sci, Beijing 100049, Peoples R China 5.Nankai Univ, Coll Environm Sci & Engn, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Tianjin Key Lab Environm Remediat & P, T 6.Univ Calif Los Angeles, Ctr Environm Implicat Nanotechnol UC CEIN, Calif NanoSyst Inst, Los Angeles, CA 90095 USA |
| 推荐引用方式 GB/T 7714 | Ma, Juan,Liu, Xinlei,Yang, Yi,et al. Binding of Benzo[a]pyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy[J]. ACS NANO,2021,15(6):9717-9731. |
| APA | Ma, Juan.,Liu, Xinlei.,Yang, Yi.,Qiu, Jiahuang.,Dong, Zheng.,...&Liu, Sijin.(2021).Binding of Benzo[a]pyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy.ACS NANO,15(6),9717-9731. |
| MLA | Ma, Juan,et al."Binding of Benzo[a]pyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy".ACS NANO 15.6(2021):9717-9731. |
入库方式： OAI收割
来源：生态环境研究中心
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