Bioassay- and QSAR-based screening of toxic transformation products and their formation under chlorination treatment on levofloxacin
文献类型：期刊论文
| 作者 | Chen, Miao ; Wei, Dongbin; Wang, Feipeng; Yin, Junxia; Li, Min; Du, Yuguo
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-07-15 |
| 卷号 | 414页码:- |
| 关键词 | Quinolone Chlorine disinfection In silico method Antibiotic activity Genotoxicity |
| ISSN号 | 0304-3894 |
| 英文摘要 | Levofloxacin (LEV) is a broad-spectrum quinolone antibiotic and widely used for human and veterinary treatment. Overuse of LEV leads to its frequent occurrence in the water environment. In this study, the transformation characteristics of LEV in water during the simulated chlorination disinfection treatment were explored. Fifteen major transformation products (TPs) of LEV were identified, and their plausible formation pathways were proposed. The reaction pathways were strongly dependent on pH condition, and LEV removal was relevant to free available chlorine (FAC) dose. Antibacterial activity of chlorination system was dramatically declined when FAC was more than 3-equivalent (eq) due to the elimination of antibacterial related functional groups. Genotoxicity of chlorination system increased more than 3 times at 0.5-eq of FAC and then decreased with increasing FAC dose, which were in accordance with the relative concentration of toxic TPs estimated by QSAR model. These results implied that the combination of bioassay, QSAR computation and chemical analysis would be an efficient method to screen toxic TPs under chlorination treatment. It is anticipated that the results of this study can provide reference for optimizing operational parameters for water disinfection treatment, and for scientifically evaluating the potential risk of quinolone antibiotics. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45669]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.North Minzu Univ, Yinchuan 750021, Ningxia, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Miao,Wei, Dongbin,Wang, Feipeng,et al. Bioassay- and QSAR-based screening of toxic transformation products and their formation under chlorination treatment on levofloxacin[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,414:-. |
| APA | Chen, Miao,Wei, Dongbin,Wang, Feipeng,Yin, Junxia,Li, Min,&Du, Yuguo.(2021).Bioassay- and QSAR-based screening of toxic transformation products and their formation under chlorination treatment on levofloxacin.JOURNAL OF HAZARDOUS MATERIALS,414,-. |
| MLA | Chen, Miao,et al."Bioassay- and QSAR-based screening of toxic transformation products and their formation under chlorination treatment on levofloxacin".JOURNAL OF HAZARDOUS MATERIALS 414(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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