Biochar Fine Particles Enhance Uptake of Benzo(a)pyrene to Macrophages and Epithelial Cells via Different Mechanisms
文献类型：期刊论文
| 作者 | Liu, Xinlei; Ma, Juan; Ji, Rong; Wang, Songfeng; Zhang, Qiurong; Zhang, Chengdong; Liu, Sijin; Chen, Wei |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
 |
| 出版日期 | 2021-03-09 |
| 卷号 | 8期号:3页码:218-223 |
| ISSN号 | 2328-8930 |
| 英文摘要 | Biochars are widely used as soil amendments and are major sources of agricultural dusts. Inhalation of biochar fine particles can increase the exposure of respiratory systems to mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are bound to the materials during pyrolysis of biomass, but the specific mechanisms are elusive. Here, we show that biochar fine particles enhance the intracellular transfer of benzo(a)pyrene (a model PAH) into the J774A.1 macrophage via the Trojan-horse mechanism; i.e., the endocytosed benzo(a)pyrene-bearing particles act as a vector to deliver benzo(a)pyrene into the cells. Notably, biochar particles are found to serve as a reservoir that continuously releases benzo(a)pyrene into the lung fluids. Thus, benzo(a)pyrene bound to biochar is available to the neighboring cells such as lung epithelial cells (tested with A549 cells), even without apparent endocytosis. The aryl hydrocarbon receptor activation tests and in vitro bioaccessibility assays further corroborate these findings, in that benzo(a)pyrene carried into the lungs by biochar fine particles is still toxic to lung cells, and the cytotoxicity can be predicted based on the bioaccessibility in lung liquids. This work unearths the cell-specific risk pathways via which biochar fine particles break respiratory defense systems by serving as both contaminant vector and reservoir. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45670]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Environm Sci, Beijing 100049, Peoples R China 2.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 4.Nankai Univ, Coll Environm Sci & Engn, Minist Educ Key Lab Pollut Proc & Environm Criter, Tianjin Key Lab Environm Remediat & Pollut |
| 推荐引用方式 GB/T 7714 | Liu, Xinlei,Ma, Juan,Ji, Rong,et al. Biochar Fine Particles Enhance Uptake of Benzo(a)pyrene to Macrophages and Epithelial Cells via Different Mechanisms[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,2021,8(3):218-223. |
| APA | Liu, Xinlei.,Ma, Juan.,Ji, Rong.,Wang, Songfeng.,Zhang, Qiurong.,...&Chen, Wei.(2021).Biochar Fine Particles Enhance Uptake of Benzo(a)pyrene to Macrophages and Epithelial Cells via Different Mechanisms.ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,8(3),218-223. |
| MLA | Liu, Xinlei,et al."Biochar Fine Particles Enhance Uptake of Benzo(a)pyrene to Macrophages and Epithelial Cells via Different Mechanisms".ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 8.3(2021):218-223. |
入库方式： OAI收割
来源：生态环境研究中心
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