Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-alpha pathways
文献类型：期刊论文
| 作者 | Sang, Chen; Song, Yu; Jin, Tong-wang; Zhang, Shuo; Fu, Linyan; Zhao, Yi; Zou, Xinxin; Wang, Zhe; Gao, Hui; Liu, Sijin |
| 刊名 | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
 |
| 出版日期 | 2021-07 |
| 卷号 | 28期号:27页码:36060-36068 |
| 关键词 | Bisphenol A Low concentration Ovarian cancer Cell proliferation Metastasis Estrogen receptor-α |
| ISSN号 | 0944-1344 |
| 英文摘要 | Bisphenol A (BPA) is a widely used raw material that can be detected both in the environment and in the human body. Due to its estrogen-like effects, wide concerns have been raised about the potential role of BPA in the initiation and development of hormone-dependent cancers. Ovarian cancer is the most common reproductive system cancer and has a high mortality rate in women. Despite recent investigations into BPA's carcinogenic effects, studies on its role in ovarian cancer development remain limited. In this study, we aimed to assess the effect of BPA at various environmentally relevant concentrations on proliferation and metastasis of ovarian cancer cells. We discovered that BPA can stimulate proliferation of OVCAR-3 ovarian cancer cells after exposure for up to 5 days. Strikingly, BPA enhanced ovarian cancer cell migration, invasion, and adhesion (to vascular endothelial cells) through upregulation of matrix metalloproteinase-2 (MMP-2), MMP-9, and intercellular cell adhesion molecule-1 (IMAC-1). The stimulatory effects of BPA on cancer cell proliferation and metastasis were reversed by treatment with an ER alpha inhibitor, but not by treatment with an ER beta inhibitor. Together, these results suggest that BPA induces proliferation and metastasis of ovarian cancer cells through ER alpha signaling pathways. This study provides new insights into the carcinogenic effects of BPA with regard to ovarian cancer. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45672]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China 2.Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 2, Harbin 150086, Heilongjiang, Peoples R China 3.Capital Med Univ, Beijing Tian Tan Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China 4.Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan, Peoples R China 5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sang, Chen,Song, Yu,Jin, Tong-wang,et al. Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-alpha pathways[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2021,28(27):36060-36068. |
| APA | Sang, Chen.,Song, Yu.,Jin, Tong-wang.,Zhang, Shuo.,Fu, Linyan.,...&Liu, Sijin.(2021).Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-alpha pathways.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,28(27),36060-36068. |
| MLA | Sang, Chen,et al."Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-alpha pathways".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 28.27(2021):36060-36068. |
入库方式： OAI收割
来源：生态环境研究中心
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