Bisphenol S Promotes the Formation of Visceral Fat in Mice
文献类型：期刊论文
| 作者 | Zhang, Wenjuan; Gao, Yue; Chen, Cheng; Li, Aijing ; Ma, Xuerui; Liang, Yong; Yao, Xinglei; Song, Maoyong; Jiang, Guibin
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
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| 出版日期 | 2021-08-10 |
| 卷号 | 8期号:8页码:699-704 |
| ISSN号 | 2328-8930 |
| 英文摘要 | Bisphenol S (BPS) is a bisphenol A (BPA) replacement that is widely present in the environment and in humans. The association between obesity and BPS has been reported in epidemiological studies; however, the obesogenic effect and related mechanism of BPS remain poorly understood. In this study, high-resolution microcomputed tomography analysis showed that the volume of visceral fat was significantly increased in BPS-treated mice. Moreover, BPS showed a higher potency to induce visceral fat formation in mice than BPA at the exposure concentration of 5 mg/kg/day for 14 days. Nontargeted metabolomic analysis showed that BPS exposure induced multiple metabolic disorders in the livers of BPS-treated mice. Interestingly, the body weight and volumes of visceral fat returned to normal by co-treatment with succinate in BPS-treated mice, suggesting that succinate might be the key molecule for the link between BPS and visceral obesity. Our findings highlight that BPS may act as an environmental obesogen to promote obesity. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45673]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wenjuan,Gao, Yue,Chen, Cheng,et al. Bisphenol S Promotes the Formation of Visceral Fat in Mice[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,2021,8(8):699-704. |
| APA | Zhang, Wenjuan.,Gao, Yue.,Chen, Cheng.,Li, Aijing.,Ma, Xuerui.,...&Jiang, Guibin.(2021).Bisphenol S Promotes the Formation of Visceral Fat in Mice.ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,8(8),699-704. |
| MLA | Zhang, Wenjuan,et al."Bisphenol S Promotes the Formation of Visceral Fat in Mice".ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 8.8(2021):699-704. |
入库方式： OAI收割
来源：生态环境研究中心
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