Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis
文献类型：期刊论文
| 作者 | Niu, Yue; Zhu, Min; Dong, Mengqi; Li, Jinbo ; Li, Yuanyuan; Xiong, Yiming; Liu, Pengyan; Qin, Zhanfen
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| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2021-08 |
| 卷号 | 237页码:- |
| ISSN号 | 0166-445X |
| 关键词 | Bisphenol A Bisphenol F Xenopus laevis Brain development Thyroid hormone signaling |
| 英文摘要 | There is concern about adverse effects of thyroid hormone (TH) disrupting chemicals on TH-dependent brain development. Bisphenol A (BPA) and its analogues, such as bisphenol F (BPF), are known to have the potential to interfere with TH signaling, but whether they affect TH-dependent brain development is not yet well documented. Here, we conducted the T3-induced Xenopus laevis metamorphosis assay, a model for studying TH signaling disruption, to investigate the effects of BPA and BPF (10-1000 nM) on TH signaling in brains and subsequent brain development. While 48-hr treatment with 1 nM T3 dramatically upregulated TH-response gene expression in X. laevis brains at stage 52, 1000 and/or 100 nM BPA also caused significant transcriptional upregulation of certain TH-response genes, whereas BPF had slighter effects, suggesting limited TH signaling disrupting activity of BPF in brains relative to BPA at the lack of TH. In the presence of 1 nM T3, 1000 and/or 100 nM of BPF as well as BPA antagonized T3-induced TH-response gene expression, whereas lower concentrations agonized T3 actions on certain TH-response genes, displaying an apparently biphasic effect on TH signaling. After 96 h exposure, T3 induced brain morphological remodeling coupled with cell proliferation and neuronal differentiation, whereas both BPA and BPF generally antagonized T3-induced changes in a concentrationdependent manner, with weak or no effects of bisphenol exposure alone. Overall, all results show that BPA and BPF interfered with TH signaling in Xenopus brains, especially in the presence of TH, and subsequently affected TH-dependent brain development. Given the evolutionary conservation of TH-dependent brain development among vertebrates, our findings from X. laevis warrant further studies to reveal potential influences of bisphenols on TH-dependent brain development in higher vertebrates. |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45674]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Shuangqing Rd, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hebei Univ, Coll Chem & Environm Sci, 1088 Wusi Rd, Baoding 071000, Hebei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Yue,Zhu, Min,Dong, Mengqi,et al. Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis[J]. AQUATIC TOXICOLOGY,2021,237:-. |
| APA | Niu, Yue.,Zhu, Min.,Dong, Mengqi.,Li, Jinbo.,Li, Yuanyuan.,...&Qin, Zhanfen.(2021).Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis.AQUATIC TOXICOLOGY,237,-. |
| MLA | Niu, Yue,et al."Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis".AQUATIC TOXICOLOGY 237(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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