Characterization of the mercury-binding proteins in tuna and salmon sashimi: Implications for health risk of mercury in food
文献类型：期刊论文
| 作者 | Nong, Qiying; Dong, Hongzhe; Liu, Yingqiu; Liu, Lihong; He, Bin; Huang, Yongshun; Jiang, Jie; Luan, Tiangang; Chen, Baowei; Hu, Ligang |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2021-01 |
| 卷号 | 263页码:- |
| 关键词 | Mercury Fish muscle Metalloproteins Beta-actin Tropomyosin Cysteine |
| ISSN号 | 0045-6535 |
| 英文摘要 | Fish consumption is one of the major ways through which humans receive exposure to mercury (Hg). The existing forms of Hg in food, particularly Hg bound to proteins, may affect the absorption of Hg by humans and subsequently its potentially toxic effects. However, the knowledge regarding Hg-binding proteins in edible fish muscle is scarce. In the present study, salmon and tuna fish muscles, collected from seven different regions and countries, were analyzed using metallomics- and proteomics-based techniques. The concentration of Hg in sashimi samples ranged from 4.4 to 317.4 ng/g. Size exclusion chromatography (SEC) coupled with inductively coupled plasma mass spectrometer (ICP-MS) showed that beta-actin was a novel Hg-binding protein from the fish muscles, and this protein could also bind bismuth (Bi), silver (Ag), and copper (Cu). Hg bound to beta-actin accounted for approximately 30.2-37.6% of the total Hg in the tuna muscles and was significantly correlated to total Hg in the fish muscles (r = 0.98, p < 0.01) and in the fraction of soluble proteins (r = 0.94, p < 0.01). These findings suggest that proteins act as the main Hg accumulation sites in edible fish; thus, increasing human exposure to Hg following gastrointestinal digestion. (C) 2020 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45680]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Sun Yat Sen Univ, Sch Marine Sci, Southern Marine Sci & Engn Guangdong Lab, Zhuhai 519082, Peoples R China 4.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China 5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 6.Guangdong Prov Hosp Occupat Dis Prevent & Treatme, Guangzhou 510300, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nong, Qiying,Dong, Hongzhe,Liu, Yingqiu,et al. Characterization of the mercury-binding proteins in tuna and salmon sashimi: Implications for health risk of mercury in food[J]. CHEMOSPHERE,2021,263:-. |
| APA | Nong, Qiying.,Dong, Hongzhe.,Liu, Yingqiu.,Liu, Lihong.,He, Bin.,...&Hu, Ligang.(2021).Characterization of the mercury-binding proteins in tuna and salmon sashimi: Implications for health risk of mercury in food.CHEMOSPHERE,263,-. |
| MLA | Nong, Qiying,et al."Characterization of the mercury-binding proteins in tuna and salmon sashimi: Implications for health risk of mercury in food".CHEMOSPHERE 263(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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