Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation
文献类型：期刊论文
| 作者 | Zhou, Pengcheng; Zheng, Ting; Li, Yunping; Zhang, Xin; Feng, Jinhong; Wei, Yunbo; Wang, Hao; Yao, Yin; Gong, Fang; Tian, Wenjing |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2021-01-19 |
| 卷号 | 55期号:2页码:1099-1109 |
| ISSN号 | 0013-936X |
| 英文摘要 | Chlorinated flame-retardant dechloranes are emerging substitutes for restricted flame retardants. Recent studies have demonstrated that they are accumulated in wildlife and detectable in humans; however, their effects on human health are poorly understood. Here, for the first time, we revealed that widely used chlorinated flame-retardant dechlorane 602 (Dec 602) exacerbated airway inflammation in two mouse models induced by house dust mite (HDM) or IL-33, respectively. Deteriorated airway inflammation by Dec 602 was associated with a higher production of type 2 cytokines including IL-4, IL-5, and IL-13, and IgE, accompanied by enhanced mRNA expression of proinflammatory cytokines such as TNF-alpha and IL-6. Mechanistically, we found that Dec 602 directly potentiated mouse and human group 2 innate lymphoid cells and, as such, promoted airway inflammation even in the absence of conventional T cells in Rag(-/-) mice. These findings provide novel immunological insights necessary for further studies of the health impact of emerging flame-retardant dechloranes including Dec 602. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45685]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Qilu Univ Technol, Sch Pharmaceut Sci, Lab Immunol Environm & Hlth, Shandong Acad Sci, Jinan 250014, Peoples R China 3.Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol & Infect Dis, Canberra, ACT 0200, Australia 4.Univ Queensland, Univ Queensland Diamantina Inst, Fac Med, Translat Res Inst, Brisbane, Qld 4102, Australia 5.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Beijing 100864, Peoples R China 6.Nanjing Univ, Affiliated Drum Tower Hosp, Dept Rheumatol & Immunol, Med Sch, Nanjing 210 |
| 推荐引用方式 GB/T 7714 | Zhou, Pengcheng,Zheng, Ting,Li, Yunping,et al. Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2021,55(2):1099-1109. |
| APA | Zhou, Pengcheng.,Zheng, Ting.,Li, Yunping.,Zhang, Xin.,Feng, Jinhong.,...&Yu, Di.(2021).Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation.ENVIRONMENTAL SCIENCE & TECHNOLOGY,55(2),1099-1109. |
| MLA | Zhou, Pengcheng,et al."Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation".ENVIRONMENTAL SCIENCE & TECHNOLOGY 55.2(2021):1099-1109. |
入库方式： OAI收割
来源：生态环境研究中心
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