Determination of 21 photoinitiators in human plasma by using high-performance liquid chromatography coupled with tandem mass spectrometry: A systemically validation and application in healthy volunteers
文献类型：期刊论文
| 作者 | Li, Juan; Zhang, Xu; Mu, Yunsong; He, Yuqing; Qiu, Tian; Li, Wenzheng; Zeng, Lixi |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2021-04-26 |
| 卷号 | 1643页码:- |
| ISSN号 | 0021-9673 |
| 关键词 | Aromatic organic pollutants Photoinitiators Human plasma Liquid-liquid extraction Solid-phase extraction HPLC-MS MS |
| 英文摘要 | In the present study, a comprehensive and sensitive method for simultaneous determination of 21 PIs (nine benzophenones, eight amine co-initiators, and four thioxanthones) in human plasma using high -performance liquid chromatography coupled with tandem mass spectrometry was developed and vali-dated. Two different pre-treatment approaches (liquid-liquid extraction (LLE) and LLE coupled with solid-phase extraction (SPE)) and eight extraction solvents were studied to optimize sample treatment to obtain good recoveries and reduce any matrix effects. The procedure of LLE + SPE was selected as final sample treatment procedure because it obtained higher recoveries as well as lower matrix effects than that per -formed by LLE alone. The recoveries of 21 target analytes at three spiked concentrations (0.05, 0.5, and 5 ng/mL) ranged from 81% to 109%. The intra-and inter-day relative standard deviations were between 2.5% and 13%. Accuracy and precision data indicated that the detection method was accurate and precise for most of the PIs. The linearities of the labeled dilution calibration curves at 10 concentration levels (iLOQ to 100 ng/mL or iLOQ to 200 ng/mL) were good with correlation coefficients ranged from 0.995 to 0.999. The method quantification limits were in the range of 1.7?16 pg/mL. The analytical method was applied to the analysis of PIs in 14 human plasma samples collected from pregnant women in Guangdong Province, China. Fifteen PIs were detected with total concentrations ranging from 318 to 2772 pg/mL. The ubiquitous contamination of human plasma with PIs suggests that there is widespread exposure to these compounds. Consequently, there should be increased awareness of these pollutants in the environment. 1 Introduction ? 2021 Elsevier B.V. All rights reserved. |
| WOS研究方向 | Biochemical Research Methods ; Chemistry, Analytical |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45700]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Jinan Univ, Guangdong Hongkong Macau Joint Lab Collaborat Inn, Guangdong Key Lab Environm Pollut & Hlth, Sch Environm, Guangzhou 511443, Peoples R China 3.Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, China CDC Key Lab Environm & Populat Hlth, Beijing 100021, Peoples R China 4.Renmin Univ China, Sch Environm & Nat Resources, Beijing 100872, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Juan,Zhang, Xu,Mu, Yunsong,et al. Determination of 21 photoinitiators in human plasma by using high-performance liquid chromatography coupled with tandem mass spectrometry: A systemically validation and application in healthy volunteers[J]. JOURNAL OF CHROMATOGRAPHY A,2021,1643:-. |
| APA | Li, Juan.,Zhang, Xu.,Mu, Yunsong.,He, Yuqing.,Qiu, Tian.,...&Zeng, Lixi.(2021).Determination of 21 photoinitiators in human plasma by using high-performance liquid chromatography coupled with tandem mass spectrometry: A systemically validation and application in healthy volunteers.JOURNAL OF CHROMATOGRAPHY A,1643,-. |
| MLA | Li, Juan,et al."Determination of 21 photoinitiators in human plasma by using high-performance liquid chromatography coupled with tandem mass spectrometry: A systemically validation and application in healthy volunteers".JOURNAL OF CHROMATOGRAPHY A 1643(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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