Developmental Toxicity of Few-Layered Black Phosphorus toward Zebrafish
文献类型：期刊论文
| 作者 | Yang, Xiaoxi; Liang, Jiefeng; Wu, Qi; Li, Min; Shan, Wanyu; Zeng, Li; Yao, Linlin; Liang, Yong; Wang, Chang; Gao, Jie |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2021-01-19 |
| 卷号 | 55期号:2页码:1134-1144 |
| ISSN号 | 0013-936X |
| 英文摘要 | Black phosphorus (BP) has extensive applications in various fields. The release of BP into aquatic ecosystems and the potential toxic effects on aquatic organisms are becoming major concerns. Here, we investigated the developmental toxicity of few-layered BP toward the zebrafish. We found that BP could adsorb on the surface of the chorion and could subsequently penetrate within the embryo. After exposure of embryos to 10 mg/L BP, developmental malformations appeared at 96 hpf, especially heart deformities such as pericardial edema and bradycardia, accompanied by severe circulatory system failure. Using transgenic zebrafish larvae, we further characterized cardiovascular defects with cardiac enlargement and impaired cardiac vessels as indicators of damage to the cardiovascular system upon BP exposure. We performed transcriptomic analysis on zebrafish embryos treated with a lower concentration of 2 mg/L. The results showed disruption in genes associated with muscle development, oxygen involved processes, focal adhesion, and VEGF and MAPK signaling pathways. These alterations also indicated that BP carries a risk of developmental perturbation at lower concentrations. This study provides new insights into the effects of BP on aquatic organisms. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45703]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 5.UCAS, Hangzhou Inst Adv Study, Inst Environm & Hlth, Hangzhou 310000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaoxi,Liang, Jiefeng,Wu, Qi,et al. Developmental Toxicity of Few-Layered Black Phosphorus toward Zebrafish[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2021,55(2):1134-1144. |
| APA | Yang, Xiaoxi.,Liang, Jiefeng.,Wu, Qi.,Li, Min.,Shan, Wanyu.,...&Jiang, Guibin.(2021).Developmental Toxicity of Few-Layered Black Phosphorus toward Zebrafish.ENVIRONMENTAL SCIENCE & TECHNOLOGY,55(2),1134-1144. |
| MLA | Yang, Xiaoxi,et al."Developmental Toxicity of Few-Layered Black Phosphorus toward Zebrafish".ENVIRONMENTAL SCIENCE & TECHNOLOGY 55.2(2021):1134-1144. |
入库方式： OAI收割
来源：生态环境研究中心
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