Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization
文献类型：期刊论文
| 作者 | Zhang, Lihui; Wei, Wei ; Liu, Zixuan; Liu, Xuting; Song, Erqun; Song, Yang
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-04-15 |
| 卷号 | 408页码:- |
| 关键词 | Silicon dioxide Nanoparticle Autophagy Corona Fibrinogen |
| ISSN号 | 0304-3894 |
| 英文摘要 | Due to the blooming development of nanotechnology, the further understanding of nanomaterials-induced toxicity has been demanded. Following their introduction into a biological matrix, the surface of nano particles (NPs) is covered by protein layer, namely corona, which imparts a new biological identity to NPs. Here, we showed that fibrinogen (Fg), but not albumin (BSA) or hemoglobin (Hb), decoration on the surface of silica nanoparticles (SiO2 NPs) ameliorate their pro-autophagic activity in non-phagocytic cells. Surprisingly, this effect of Fg was compromised in phagocytic cells. Further mechanistic investigation suggested coronal Fg has dual effects on the tuning of SiO2 NPs-induced autophagic response. First, Fg decoration blocks SiO2 NPs sedimentation through stabilize SiO2 NPs suspension; secondly, Fg coverage inhibits SiO2 NPs' cellular internalization. These findings provided important insights into the understanding of NPs-corona complexes behaviors and indicate future directions for the investigation of corona-mediated biological activities. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45710]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, 2 Tiansheng Rd, Chongqing 400715, Peoples R China 2.Tongren Polytech Coll, Sch Pharmaceut Sci, Tongren 554300, Guizhou, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lihui,Wei, Wei,Liu, Zixuan,et al. Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,408:-. |
| APA | Zhang, Lihui,Wei, Wei,Liu, Zixuan,Liu, Xuting,Song, Erqun,&Song, Yang.(2021).Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization.JOURNAL OF HAZARDOUS MATERIALS,408,-. |
| MLA | Zhang, Lihui,et al."Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization".JOURNAL OF HAZARDOUS MATERIALS 408(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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