Effects of PM2.5 exposure on reproductive system and its mechanisms
文献类型：期刊论文
| 作者 | Wang, Lingjuan; Luo, Dan; Liu, Xiaolong; Zhu, Jianqiang; Wang, Fengli; Li, Bin; Li, Liming |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2021-02 |
| 卷号 | 264页码:- |
| 关键词 | PM2.5 Reproductive toxicity Male infertility Mechanism ROS |
| ISSN号 | 0045-6535 |
| 英文摘要 | With the development of human society, haze has become an important form of air pollution. Haze is a mixture of fog and haze, and the main component of haze is fine particulate matter (PM2.5), which is the most important indicator of composite air pollution. Epidemiological studies proved that PM2.5 can break through the respiratory mucosal barrier and enter the human body, causing pathological effects on multiple systems of the body. In the past, people put more attention to PM2.5 in the respiratory system, cardiovascular system, nervous system, etc, and relatively paid less attention to the reproductive system. Recent studies have shown that PM2.5 will accumulate in the reproductive organs through blood-testis barrier, placental barrier, epithelial barrier and other barriers protecting reproductive tissues. In addition, PM2.5 can disrupt hormone levels, ultimately affecting fertility. Prior studies have shown that oxidative stress, inflammation, apoptosis, and the breakdown of barrier structures are now considered to contribute to reproductive toxicity and may cause damage at the molecular and genetic levels. However, the exact mechanism remains to be elucidated. Our review aims to provide an understanding of the pathological effects of PM2.5 on reproductive system and the existing injury mechanism. (C) 2020 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45715]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Tianjin 300211, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Reprod Hlth, Wuhan 430030, Peoples R China 3.940th Hosp Joint Logist Support Force Peoples Lib, Dept Cardiovasc Surg, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 5.Tianjin Med Univ, Hosp 2, Tianjin Inst Urol, Dept Urol, Tianjin 300211, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lingjuan,Luo, Dan,Liu, Xiaolong,et al. Effects of PM2.5 exposure on reproductive system and its mechanisms[J]. CHEMOSPHERE,2021,264:-. |
| APA | Wang, Lingjuan.,Luo, Dan.,Liu, Xiaolong.,Zhu, Jianqiang.,Wang, Fengli.,...&Li, Liming.(2021).Effects of PM2.5 exposure on reproductive system and its mechanisms.CHEMOSPHERE,264,-. |
| MLA | Wang, Lingjuan,et al."Effects of PM2.5 exposure on reproductive system and its mechanisms".CHEMOSPHERE 264(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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