Efforts toward rational design of Th2-bias immune stimulator through modification on D-Gal-C-4 of alpha-GalCer derivative
文献类型：期刊论文
| 作者 | Zhao, Chuanfang; Hu, Liyan; Ma, Juan; Cui, Wei; Jing, Yang; Du, Yuguo |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2021-06-04 |
| 卷号 | 89页码:- |
| 关键词 | KRN7000 alpha-GalCer Th2 cytokines iNKT cells Autoimmune disease |
| ISSN号 | 0040-4020 |
| 英文摘要 | alpha-Galactosylceramide (alpha-GalCer) initiates immune response by activating iNKT cells in a CD1d restricted way. However, its clinical application is quite limited mainly because of the simultaneous secretion of antagonizing Th1- and Th2-type cytokines. With the help of molecular computation, we conducted a rational design of glycolipid to expect a Th2-bias immune response. Accordingly, some of the designed D-galactopyranosyl lipids were synthesized, and their abilities to induce Th2 cytokines through stimulating iNKT cells were investigated both in vitro and in vivo. We found that modification on Gal-C-4 of glycolipids could possibly increase Th2-selecivity, although the cytokine productivity was suppressed ascribing to the weaken interaction of CD1d and TCR in CD1d/glycolipid/TCR triplex. (C) 2021 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Chemistry, Organic |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45718]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 3.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Chuanfang,Hu, Liyan,Ma, Juan,et al. Efforts toward rational design of Th2-bias immune stimulator through modification on D-Gal-C-4 of alpha-GalCer derivative[J]. TETRAHEDRON,2021,89:-. |
| APA | Zhao, Chuanfang,Hu, Liyan,Ma, Juan,Cui, Wei,Jing, Yang,&Du, Yuguo.(2021).Efforts toward rational design of Th2-bias immune stimulator through modification on D-Gal-C-4 of alpha-GalCer derivative.TETRAHEDRON,89,-. |
| MLA | Zhao, Chuanfang,et al."Efforts toward rational design of Th2-bias immune stimulator through modification on D-Gal-C-4 of alpha-GalCer derivative".TETRAHEDRON 89(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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