Emerging investigator series: chemical transformation of silver and zinc oxide nanoparticles in simulated human tear fluids: influence of biocoronae
文献类型：期刊论文
| 作者 | Li, Lingxiangyu; Khan, Ashfeen Ubaid; Zhang, Xiang; Qian, Xiaoting; Wang, Yawei |
| 刊名 | ENVIRONMENTAL SCIENCE-NANO
 |
| 出版日期 | 2021-09-01 |
| 卷号 | 8期号:9页码:2430-2440 |
| ISSN号 | 2051-8153 |
| 英文摘要 | With the rapid development of nanotechnology, personal care products with silver nanoparticles (Ag-NPs) or zinc oxide nanoparticles (ZnO-NPs) are being widely used because of their superior antibacterial efficacies. Biological fluids would thus inevitably interact with Ag-NPs or ZnO-NPs. Human tear fluid is an important model that was ignored in past studies, restricting the comprehensive understanding of the stability and health risks of Ag-NPs and ZnO-NPs. Herein, two simulated tear fluid models were examined, allowing us to understand potential transformations that can affect the properties and toxicity of Ag-NPs and ZnO-NPs. Both Ag-NPs and ZnO-NPs exhibited high chemical stability in the simulated tear fluid containing proteins even after an incubation time of 168 h due to the formation of biocoronae on the particles, resulting in inferior antibacterial activities of Ag-NPs and ZnO-NPs to E. coli. Nevertheless, Ag-NPs and ZnO-NPs could gradually transform into AgCl and Zn-5(CO3)(2)(OH)(6) respectively in the simulated tear fluid without protein, wherein AgCl or Zn-5(CO3)(2)(OH)(6) accounted for 59.7% of silver or 91.7% of zinc through a selective dissolution method established in this study. The size of AgCl particles was far smaller than that of pristine Ag-NPs, whereas Zn-5(CO3)(2)(OH)(6) exhibited a needle-crossed morphology with a large size compared to pristine ZnO-NPs. An enhanced antibacterial efficacy was observed for the transformed Ag-NPs relative to that for pristine Ag-NPs, since high concentrations of dissolved silver were detected in the culture medium with the transformed Ag-NPs. Compared to pristine ZnO-NPs, in contrast, the transformed ZnO-NPs showed moderate antibacterial activity to E. coli. In total, the chemical stability of Ag-NPs and ZnO-NPs in the simulated tear fluid was highly affected by the protein, which would further influence their antibacterial efficacies. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Environmental Sciences ; Nanoscience & Nanotechnology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45719]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Peoples R China 2.Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lingxiangyu,Khan, Ashfeen Ubaid,Zhang, Xiang,et al. Emerging investigator series: chemical transformation of silver and zinc oxide nanoparticles in simulated human tear fluids: influence of biocoronae[J]. ENVIRONMENTAL SCIENCE-NANO,2021,8(9):2430-2440. |
| APA | Li, Lingxiangyu,Khan, Ashfeen Ubaid,Zhang, Xiang,Qian, Xiaoting,&Wang, Yawei.(2021).Emerging investigator series: chemical transformation of silver and zinc oxide nanoparticles in simulated human tear fluids: influence of biocoronae.ENVIRONMENTAL SCIENCE-NANO,8(9),2430-2440. |
| MLA | Li, Lingxiangyu,et al."Emerging investigator series: chemical transformation of silver and zinc oxide nanoparticles in simulated human tear fluids: influence of biocoronae".ENVIRONMENTAL SCIENCE-NANO 8.9(2021):2430-2440. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。