Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid*
文献类型：期刊论文
| 作者 | Wang, Lixin; Wang, Yingxue; Xu, Man; Ma, Juan; Zhang, Shuping ; Liu, Sijin; Wang, Ke; Tian, Huifang; Cui, Jiansheng
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-05-15 |
| 卷号 | 410页码:- |
| 关键词 | Polystyrene microplastics Transformation Physicochemical alterations Enhanced hepatic Cytotoxicity Simulated gastric fluid |
| ISSN号 | 0304-3894 |
| 英文摘要 | Microplastics pollution has emerged as one of the top-ranked global environmental issues, receiving worldwide attention in recent years. However, knowledge about the detrimental effects of microplastics on human health is still limited. In real-world settings, the physicochemical characteristics of microplastics were modified by environmental and biological transformation, largely changing their ultimate toxicity. Nonetheless, the toxicity change related to transformation of microplastics has not been considered in most published studies thus far. In the current study, we investigated the cytotoxicity of transformed polystyrene microplastics in hepatocytes. Our results revealed that 500 nm polystyrene microplastics, which were chemically transformed by simulated gastric fluid, exacerbated their adverse effects on SMMC-7721 cells at 20 ?g/mL for 24 h treatment, including morphological alteration, membrane damage and increased cell apoptosis via oxidative stress. This exacerbated cytotoxicity could be at least partially explained by the degradation, changed surface charge and altered surface chemistry of these polystyrene microplastics after transformation. In conclusion, our study demonstrates that the hepatic cytotoxicity of polystyrene microplastics is enhanced after transformation. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45721]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Hebei Univ Sci & Technol, Pollut Prevent Biotechnol Lab Hebei Prov, Coll Environm Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China 2.Hebei Key Lab Mol Chem Drug, Shijiazhuang 050018, Hebei, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Shandong First Med Univ, Affiliated Hosp 1, Jinan 250014, Peoples R China 5.Shijiazhuang Ctr Dis Control & Prevent, Shijiazhuang 050011, Hebei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lixin,Wang, Yingxue,Xu, Man,et al. Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid*[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,410:-. |
| APA | Wang, Lixin.,Wang, Yingxue.,Xu, Man.,Ma, Juan.,Zhang, Shuping.,...&Cui, Jiansheng.(2021).Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid*.JOURNAL OF HAZARDOUS MATERIALS,410,-. |
| MLA | Wang, Lixin,et al."Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid*".JOURNAL OF HAZARDOUS MATERIALS 410(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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