Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways*
文献类型：期刊论文
| 作者 | Qie, Yu; Qin, Weiping; Zhao, Keda; Liu, Chang; Zhao, Lixia; Guo, Liang-Hong |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2021-06-01 |
| 卷号 | 278页码:- |
| 关键词 | Environmental estrogen Estrogenic effect GPER ERs Crosstalk |
| ISSN号 | 0269-7491 |
| 英文摘要 | Many environmental chemicals have been found to exert estrogenic effects in cells and experimental animals by activating nuclear receptors such as estrogen receptors and estrogen-related receptors. These compounds include bisphenols, pesticides, polybrominated diphenyl ethers (PBDEs), organophosphate flame retardants, phthalates and metalloestrogens. G protein-coupled estrogen receptor (GPER) exists widely in numerous cells/tissues of human and other vertebrates. A number of studies have demonstrated that GPER plays a vital role in mediating the estrogenic effects of environmental pollutants. Even at very low concentrations, these chemicals may activate GPER pathways, thus affect many aspects of cellular functions including proliferation, metastasis and apoptosis, resulting in cancer progression, cardiovascular disorders, and reproductive dysfunction. This review summarized the environmental occurrence and human exposure levels of these pollutants, and integrated current experimental evidence toward revealing the underlying mechanisms of pollutant-induced cellular dysfunction via GPER. The GPER mediated rapid non-genomic actions play an important role in the process leading to the adverse effects observed in experimental animals and even in human beings. 0 2021 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45724]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.China Jiliang Univ, Inst Environm & Hlth Sci, 168 Xueyuan St, Hangzhou 310018, Zhejiang, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Wuhan, Hubei, Peoples R China 5.UCAS, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qie, Yu,Qin, Weiping,Zhao, Keda,et al. Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways*[J]. ENVIRONMENTAL POLLUTION,2021,278:-. |
| APA | Qie, Yu,Qin, Weiping,Zhao, Keda,Liu, Chang,Zhao, Lixia,&Guo, Liang-Hong.(2021).Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways*.ENVIRONMENTAL POLLUTION,278,-. |
| MLA | Qie, Yu,et al."Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways*".ENVIRONMENTAL POLLUTION 278(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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