First Total Synthesis of 27-Deoxylyngbyabellin A
文献类型：期刊论文
| 作者 | Zhang, Yang; Liu, Yi; Du, Yuguo |
| 刊名 | SYNTHESIS-STUTTGART
 |
| 出版日期 | 2021-08-17 |
| 卷号 | 53期号:16页码:2874-2880 |
| 关键词 | total synthesis cyclic peptides 27-deoxylyngbyabellin A thiazoles antitumor agents |
| ISSN号 | 0039-7881 |
| 英文摘要 | In this study, we document the first total synthesis of the marine cyanobacteria secondary metabolite 27-deoxylyngbyabellin A in 10 linear steps with 9.7% overall yield. Key steps entailed (1) one-pot cascade reaction of (S)-2-(benzyloxy)-3-methylbutanoic acid and of Boc-L-Ile-OH with a beta-azido disulfide building block to access two critical thiazole units, (2) chiral oxazaborolidinone-mediated asymmetric aldol reaction to construct an (S)-.-hydroxy ester, and (3) diphenyl phosphorazidate mediated macrolactamization of the assembled linear precursor to achieve the natural product 27-deoxylyngbyabellin A. |
| WOS研究方向 | Chemistry, Organic |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45730]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yang,Liu, Yi,Du, Yuguo. First Total Synthesis of 27-Deoxylyngbyabellin A[J]. SYNTHESIS-STUTTGART,2021,53(16):2874-2880. |
| APA | Zhang, Yang,Liu, Yi,&Du, Yuguo.(2021).First Total Synthesis of 27-Deoxylyngbyabellin A.SYNTHESIS-STUTTGART,53(16),2874-2880. |
| MLA | Zhang, Yang,et al."First Total Synthesis of 27-Deoxylyngbyabellin A".SYNTHESIS-STUTTGART 53.16(2021):2874-2880. |
入库方式： OAI收割
来源：生态环境研究中心
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