Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins
文献类型：期刊论文
| 作者 | Xu, Chi ; Wang, Kunran; Gao, Lirong; Zheng, Minghui; Li, Jingguang; Zhang, Lei; Wu, Yongning; Qiao, Lin; Huang, Di; Wang, Shuang
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| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2021-06-15 |
| 卷号 | 279页码:- |
| ISSN号 | 0269-7491 |
| 关键词 | Short-chain chlorinated paraffin Medium-chain chlorinated paraffin Temporal trend Health risk Breast milk |
| 英文摘要 | Short-chain chlorinated paraffins (SCCPs) are persistent organic pollutants which are toxic to human. Median-chain chlorinated paraffins (MCCPs) have similar toxicity to SCCPs. The productions of chlori-nated paraffins (CPs) in China were 1 million tons in 2013 and remained high after that, which may lead to high risks for human exposure to CPs. To investigate temporal trends and health risks of SCCPs and MCCPs in breast milk in China, samples (n = 2020) were collected from urban and rural areas of 11 Chinese provinces in 2017 and mixed into 42 pooled samples. SCCPs and MCCPs were analyzed by two-dimensional gas chromatography with electron-capture negative-ionization mass spectrometry (GC x GC-ECNI-MS). The MCCP concentrations (median (range)) were 472 (94-1714) and 567 (211-1089) ng g(-1) lipid in urban and rural areas, respectively, which showed continuously rapidly increasing during 2007-2017. The SCCP concentrations (median (range)) were 393 (131-808) and 525 (139-1543) ng g(-1) lipid in urban and rural areas, respectively. The results showed SCCP levels decreased in urban areas between 2007 and 2017. Significant increases in MCCP/SCCP ratios might arise from extensive manufacturing and use of MCCPs. The median estimated dietary intake via breast milk in urban and rural samples were 1230 and 2510 ng kg(-1) d(-1), respectively, for SCCPs and 2150 and 1890 ng kg(-1) d(-1), respectively, for MCCPs. Preliminarily risk assessment showed that SCCPs posed a significant health risk to infants via breastfeeding. The high MCCP levels should also be of concern because of continuous growth and negative effect on infants. Correspondence analysis indicated congeners with higher carbon and chlorine numbers in dietary tend to accumulate in breast milk. (C) 2021 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45743]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China 2.Chinese Acad Med Sci 2019RU014, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, F 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Chi,Wang, Kunran,Gao, Lirong,et al. Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins[J]. ENVIRONMENTAL POLLUTION,2021,279:-. |
| APA | Xu, Chi.,Wang, Kunran.,Gao, Lirong.,Zheng, Minghui.,Li, Jingguang.,...&Li, Da.(2021).Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins.ENVIRONMENTAL POLLUTION,279,-. |
| MLA | Xu, Chi,et al."Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins".ENVIRONMENTAL POLLUTION 279(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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