Identification, Quantification, and Imaging of the Biodistribution of Soot Particles by Mass Spectral Fingerprinting
文献类型：期刊论文
| 作者 | Lin, Yue; Huang, Xiu; Liu, Yongchun; Cao, Dong ; Lu, Dawei; Feng, Zeming; Liu, Qian; Lin, Zhenyu; Jiang, Guibin
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| 刊名 | ANALYTICAL CHEMISTRY
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| 出版日期 | 2021-05-04 |
| 卷号 | 93期号:17页码:6665-6672 |
| ISSN号 | 0003-2700 |
| 英文摘要 | Soot is ubiquitous and has large detrimental effects on climate, air quality, and human health. However, identification of soot in carbonaceous media is very challenging due to its nanoscale carbon nature and complex sources. Due to the shortage in the methodology, until now, the fate and health effect of soot particles after inhalation are still poorly understood. Here, we report a new method for label-free identification, quantification, and imaging of soot particles in complex media based on laser desorption/ionization mass spectrometry fingerprinting. We found that soot particles from different origins and with different morphologies showed highly consistent mass spectral fingerprints deriving from peak ratios of small carbon cluster anions (C-2(-)-C-10(-)), which enabled both accurate quantification of soot in fine particulate matter (PM2.5) samples and label-free imaging of soot particles in biological media. By using this technique, we tracked and imaged the suborgan distribution of soot particles in mice after exposure to PM2.5. The results showed that the lung is the main target organ for short-term inhalation exposure to soot particles. This study helps to better understand the inhalation toxicology of soot and also provides a practical novel methodological platform for identification, tracing, and toxicological studies of elemental carbon-based nanomaterials. |
| WOS研究方向 | Chemistry, Analytical |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45750]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, F 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 4.Beijing Univ Chem Technol, Adv Innovat Ctr Soft Matter Sci & Engn, Aerosol & Haze Lab, Beijing 100029, Peoples R China 5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Yue,Huang, Xiu,Liu, Yongchun,et al. Identification, Quantification, and Imaging of the Biodistribution of Soot Particles by Mass Spectral Fingerprinting[J]. ANALYTICAL CHEMISTRY,2021,93(17):6665-6672. |
| APA | Lin, Yue.,Huang, Xiu.,Liu, Yongchun.,Cao, Dong.,Lu, Dawei.,...&Jiang, Guibin.(2021).Identification, Quantification, and Imaging of the Biodistribution of Soot Particles by Mass Spectral Fingerprinting.ANALYTICAL CHEMISTRY,93(17),6665-6672. |
| MLA | Lin, Yue,et al."Identification, Quantification, and Imaging of the Biodistribution of Soot Particles by Mass Spectral Fingerprinting".ANALYTICAL CHEMISTRY 93.17(2021):6665-6672. |
入库方式： OAI收割
来源：生态环境研究中心
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