In vivo and in vitro transcriptomics meta-analyses reveal that BPA may affect TGF-beta signaling regardless of the toxicology system employed
文献类型：期刊论文
| 作者 | Lu, Yuanping; Yang, Renjun; Yin, Nuoya; Faiola, Francesco |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2021-09-15 |
| 卷号 | 285页码:- |
| 关键词 | Bisphenol A TGF-Beta signaling Data integration Developmental toxicity Stem cell toxicology |
| ISSN号 | 0269-7491 |
| 英文摘要 | Bisphenol A (BPA) is a high-production-volume monomer for the manufacture of a wide variety of polycarbonate plastics and resins. Evidence suggests BPA can induce carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of the brain or nervous system. However, whether BPA affects the very same basic molecular processes in all the in vivo and in vitro systems employed to exert its molecular mechanisms of toxicity remains to be clarified. In this study, we collected multi-source global transcriptomics datasets for BPA-exposed organisms and cells, and evaluated the adverse effects of BPA by using data integration and gene functional enrichment analyses. We found that BPA may affect basic cellular processes, such as cell growth, survival, proliferation, differentiation, and apoptosis, independent of species and specific in vivo or in vitro systems. Mechanistically, BPA could regulate cell-extra cellular matrix interactions via challenging TGF-beta signaling pathways. Furthermore, we compared our in vitro BPA-dependent mouse embryoid body (EB) global differentiation transcriptomics with all the other datasets. We verified the EB-based toxicological system could recapitulate several in vivo and other in vitro findings very efficiently, and in a less time- and resourceconsuming fashion. Taken together, this study emphasizes the utility of meta-analyses to understand common molecular mechanisms of toxicity of synthetic chemicals. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45754]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yuanping,Yang, Renjun,Yin, Nuoya,et al. In vivo and in vitro transcriptomics meta-analyses reveal that BPA may affect TGF-beta signaling regardless of the toxicology system employed[J]. ENVIRONMENTAL POLLUTION,2021,285:-. |
| APA | Lu, Yuanping,Yang, Renjun,Yin, Nuoya,&Faiola, Francesco.(2021).In vivo and in vitro transcriptomics meta-analyses reveal that BPA may affect TGF-beta signaling regardless of the toxicology system employed.ENVIRONMENTAL POLLUTION,285,-. |
| MLA | Lu, Yuanping,et al."In vivo and in vitro transcriptomics meta-analyses reveal that BPA may affect TGF-beta signaling regardless of the toxicology system employed".ENVIRONMENTAL POLLUTION 285(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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