Inflammatory response induced by black phosphorus nanosheets in mice and macrophages
文献类型：期刊论文
| 作者 | Qin, Hua; Chen, Jiao; Li, Yang; Gao, Lifang; Wang, Ji; Qu, Guangbo; Yang, Man; Zhou, Xianqing; Sun, Zhiwei |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2021-08-15 |
| 卷号 | 782页码:- |
| ISSN号 | 0048-9697 |
| 关键词 | Black phosphorus Inflammation Mice Macrophages |
| 英文摘要 | Black phosphorus nanosheets (BPs) belong to a type of two-dimensional layered materials and have garnered significant attention due to their diverse potential in nanomedical applications. Until recently, BPs have been increasingly applied in the biomedical field due to their excellent physical and chemical properties, as well as good biocompatibility. However, there has not been much concern about their potential toxic effects or biological effects on physiological systems. Herein, we found that BPs induced a reversible inflammatory response in mice, and then the detailed multifactorial inflammatory effects were studied among mouse macrophages. The treatment with BPs can induce higher levels of reactive oxygen species (ROS) in mouse bone marrow-derived macro-phages (BMDMs), leading to significant changes in cell survival rate, apoptosis, and inflammatory cytokines. The molecular levels of nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-kappa B) and nitric oxide (NO) in the treated cells were evaluated. The results indicated a significant increase in the expression of these molecules, suggesting an expansion of inflammatory reactions. The protein expression of heme oxygenase-1 (HO-1) molecules was decreased in BP-treated groups of cells, which indicates that BPs may inhibit anti-inflammatory effects of cells, leading to aggravation of inflammation. These findings provide evidence for biointeractions of BPs in physiological systems and may be helpful for the safe use of BP-based therapies. (C) 2021 Elsevier B.V. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45756]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Capital Med Univ, Sch Publ Hlth, Beijing, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Capital Med Univ, Beijing Key Lab Environm Toxicol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Hua,Chen, Jiao,Li, Yang,et al. Inflammatory response induced by black phosphorus nanosheets in mice and macrophages[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,782:-. |
| APA | Qin, Hua.,Chen, Jiao.,Li, Yang.,Gao, Lifang.,Wang, Ji.,...&Sun, Zhiwei.(2021).Inflammatory response induced by black phosphorus nanosheets in mice and macrophages.SCIENCE OF THE TOTAL ENVIRONMENT,782,-. |
| MLA | Qin, Hua,et al."Inflammatory response induced by black phosphorus nanosheets in mice and macrophages".SCIENCE OF THE TOTAL ENVIRONMENT 782(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。