Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles
文献类型：期刊论文
| 作者 | Andrikopoulos, Nicholas; Song, Zhiyuan; Wan, Xulin; Douek, Alon M.; Javed, Ibrahim; Fu, Changkui; Xing, Yanting; Xin, Fangyun; Li, Yuhuan; Kakinen, Aleksandr |
| 刊名 | CHEMISTRY OF MATERIALS
 |
| 出版日期 | 2021-08-24 |
| 卷号 | 33期号:16页码:6484-6500 |
| ISSN号 | 0897-4756 |
| 英文摘要 | Amyloid aggregation is a ubiquitous form of protein misfolding underlying the pathologies of Alzheimer's disease (AD), Parkinson's disease (PD), and type 2 diabetes (T2D), three primary forms of human amyloid diseases. While much has been learned about the origin, diagnosis, and management of these neurological and metabolic disorders, no cure is currently available due in part to the dynamic and heterogeneous nature of the toxic oligomers induced by amyloid aggregation. Here, we synthesized beta-casein-coated iron oxide nanoparticles (beta Cas IONPs) via a 2-(bis-((phosphonic acid)methyl)amino)ethyl-(poly(oligo ethylene glycol)methyl ether acrylate)-b-(poly(N-ethyl-2,3-dibromomaleimide)acrylate)-((butylthio)-carbonothioyl)thio propionate (BPA-P(OEGA-b-DBM)) block copolymer linker. Using a thioflavin T kinetic assay, transmission electron microscopy, Fourier transform infrared spectroscopy, discrete molecular dynamics simulations, and cell viability assays, we examined the Janus characteristics and the inhibition potential of beta Cas IONPs against the aggregation of amyloid beta (A beta), alpha synuclein (alpha S), and human islet amyloid polypeptide (IAPP), which are implicated in the pathologies of AD, PD, and T2D. Incubation of zebrafish embryos with the amyloid proteins largely inhibited hatching and elicited reactive oxygen species, which were effectively rescued by the inhibitor. Furthermore, A beta-induced damage to the mouse brain was mitigated in vivo with the inhibitor. This study revealed the potential of Janus nanoparticles as a new nanomedicine against a diverse range of amyloid diseases. |
| WOS研究方向 | Chemistry, Physical ; Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45758]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia 2.Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA 3.Southwest Univ, Coll Food Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China 4.Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, Australia 5.Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia 6.Dalian Maritime Univ, Sch Sci, Dalian 116026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Andrikopoulos, Nicholas,Song, Zhiyuan,Wan, Xulin,et al. Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles[J]. CHEMISTRY OF MATERIALS,2021,33(16):6484-6500. |
| APA | Andrikopoulos, Nicholas.,Song, Zhiyuan.,Wan, Xulin.,Douek, Alon M..,Javed, Ibrahim.,...&Ke, Pu Chun.(2021).Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles.CHEMISTRY OF MATERIALS,33(16),6484-6500. |
| MLA | Andrikopoulos, Nicholas,et al."Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles".CHEMISTRY OF MATERIALS 33.16(2021):6484-6500. |
入库方式： OAI收割
来源：生态环境研究中心
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