Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications
文献类型：期刊论文
| 作者 | Zheng, Huizhen; Jiang, Jun; Xu, Shujuan; Liu, Wei; Xie, Qianqian; Cai, Xiaoming; Zhang, Jie; Liu, Sijin; Li, Ruibin |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2021-01-28 |
| 卷号 | 13期号:4页码:2266-2285 |
| ISSN号 | 2040-3364 |
| 英文摘要 | Although ferroptosis is an iron-dependent cell death mechanism involved in the development of some severe diseases (e.g., Parkinsonian syndrome, stroke and tumours), the combination of nanotechnology with ferroptosis for the treatment of these diseases has attracted substantial research interest. However, it is challenging to differentiate nanoparticle-induced ferroptosis from other types of cell deaths (e.g., apoptosis, pyroptosis, and necrosis), elucidate the detailed mechanisms and identify the key property of nanoparticles responsible for ferroptotic cell deaths. Therefore, a summary of these aspects from current research on nano-ferroptosis is important and timely. In this review, we endeavour to summarize some convincing techniques that can be employed to specifically examine ferroptotic cell deaths. Then, we discuss the molecular initiating events of nanosized ferroptosis inducers and the cascade signals in cells, and therefore elaborate the ferroptosis mechanisms. Besides, the key physicochemical properties of nano-inducers are also discussed to acquire a fundamental understanding of nano-structure-activity relationships (nano-SARs) involved in ferroptosis, which may facilitate the design of nanomaterials to deliberately tune ferroptosis. Finally, future perspectives on the fundamental understanding of nanoparticle-induced ferroptosis and its applications are provided. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45788]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong First Med Univ & Shandong Acad Med Sci, Biomed Sci Coll, Jinan 250062, Shandong, Peoples R China 2.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiol Med,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China 4.Soochow Univ, Sch Publ Hlth, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Suzhou 215123, Jiangsu, Peoples R China 5.Shandong First Med Univ & Shandong Acad Med Sci, Shandong Med Biotechnol Ctr, Jinan 250062, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Huizhen,Jiang, Jun,Xu, Shujuan,et al. Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications[J]. NANOSCALE,2021,13(4):2266-2285. |
| APA | Zheng, Huizhen.,Jiang, Jun.,Xu, Shujuan.,Liu, Wei.,Xie, Qianqian.,...&Li, Ruibin.(2021).Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications.NANOSCALE,13(4),2266-2285. |
| MLA | Zheng, Huizhen,et al."Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications".NANOSCALE 13.4(2021):2266-2285. |
入库方式： OAI收割
来源：生态环境研究中心
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