Nanotechnology: new opportunities for the development of patch-clamps
文献类型：期刊论文
| 作者 | Gao, Jia; Liao, Chunyang; Liu, Sijin; Xia, Tian; Jiang, Guibin
|
| 刊名 | JOURNAL OF NANOBIOTECHNOLOGY
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 19期号:1页码:- |
| 关键词 | Electrophysiology Intracellular recording Nanoelectrode Field-effect transistors (FETs) Neuronal activity |
| 英文摘要 | The patch-clamp technique is one of the best approaches to investigate neural excitability. Impressive improvements towards the automation of the patch-clamp technique have been made, but obvious limitations and hurdles still exist, such as parallelization, volume displacement in vivo, and long-term recording. Nanotechnologies have provided opportunities to overcome these hurdles by applying electrical devices on the nanoscale. Electrodes based on nanowires, nanotubes, and nanoscale field-effect transistors (FETs) are confirmed to be robust and less invasive tools for intracellular electrophysiological recording. Research on the interface between the nanoelectrode and cell membrane aims to reduce the seal conductance and further improve the recording quality. Many novel recording approaches advance the parallelization, and precision with reduced invasiveness, thus improving the overall intracellular recording system. The combination of nanotechnology and the present intracellular recording framework is a revolutionary and promising orientation, potentially becoming the next generation electrophysiological recording technique and replacing the conventional patch-clamp technique. Here, this paper reviews the recent advances in intracellular electrophysiological recording techniques using nanotechnology, focusing on the design of noninvasive and greatly parallelized recording systems based on nanoelectronics. |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45790]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 3.Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90024 USA |
| 推荐引用方式 GB/T 7714 | Gao, Jia,Liao, Chunyang,Liu, Sijin,et al. Nanotechnology: new opportunities for the development of patch-clamps[J]. JOURNAL OF NANOBIOTECHNOLOGY,2021,19(1):-. |
| APA | Gao, Jia,Liao, Chunyang,Liu, Sijin,Xia, Tian,&Jiang, Guibin.(2021).Nanotechnology: new opportunities for the development of patch-clamps.JOURNAL OF NANOBIOTECHNOLOGY,19(1),-. |
| MLA | Gao, Jia,et al."Nanotechnology: new opportunities for the development of patch-clamps".JOURNAL OF NANOBIOTECHNOLOGY 19.1(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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