Neurotoxicity Induced by Atmospheric Fine Particulate Matters and the Underlying Molecular Mechanism
文献类型：期刊论文
| 作者 | Zhang, Yuzhu; Zhan, Jing; Liu, Qian; Zhou, Qunfang; Jiang, Guibin
|
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2021-05-20 |
| 卷号 | 33期号:5页码:713-725 |
| 关键词 | atmospheric fine particulate matters neurotoxicity epidemiological study molecular mechanism |
| ISSN号 | 1005-281X |
| 英文摘要 | The health effect of atmospheric fine particulate matters(PMs) is now being increasingly concerned. and a growing number of epidemiological studies have reported the adverse impacts of PMs on the respiratory system, cardiovascular system, etc. However, whether PMs can enter the brain and cause neurotoxicities or not remains unknown, which has been an important research direction for the health risk evaluation of atmospheric smog in recent years. Based on the relevant epidemiological studies and experimental evidences in vitro and in vivo, this paper summarizes the potential pathways regulating the neurotoxicity of atmospheric PMs, their detrimental effects on the adult, elderly, and developmental nervous systems, as well as the underlying molecular mechanisms. Atmospheric PMs were reported to affect the nervous system through the blood-brain barrier pathway. the olfactory nerve pathway. the microbiota-gut-brain axis, etc. Herein, oxidative stress, mitochondrial damage, inflammation. DNA damage, epigenetic regulation, hematological homeostasis, and several key signaling pathways were found to be involved in the observed neurotoxicities caused by atmospheric PM exposure. This review aims to reveal the neurotoxicities of atmospheric PMs, especially their neurodevelopmental effects on special populations such as children. On this basis. this article points out the future research directions in this field. providing a theoretical basis for the evaluation of neurotoxicities and public health hazards of atmospheric PMs. |
| WOS研究方向 | Chemistry, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45792]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuzhu,Zhan, Jing,Liu, Qian,et al. Neurotoxicity Induced by Atmospheric Fine Particulate Matters and the Underlying Molecular Mechanism[J]. PROGRESS IN CHEMISTRY,2021,33(5):713-725. |
| APA | Zhang, Yuzhu,Zhan, Jing,Liu, Qian,Zhou, Qunfang,&Jiang, Guibin.(2021).Neurotoxicity Induced by Atmospheric Fine Particulate Matters and the Underlying Molecular Mechanism.PROGRESS IN CHEMISTRY,33(5),713-725. |
| MLA | Zhang, Yuzhu,et al."Neurotoxicity Induced by Atmospheric Fine Particulate Matters and the Underlying Molecular Mechanism".PROGRESS IN CHEMISTRY 33.5(2021):713-725. |
入库方式： OAI收割
来源：生态环境研究中心
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