On the developmental toxicity of silver nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Jie; Liu, Sijin; Han, Jinxiang; Wang, Zhe; Zhang, Shuping
|
| 刊名 | MATERIALS & DESIGN
 |
| 出版日期 | 2021-05 |
| 卷号 | 203页码:- |
| 关键词 | Silver nanoparticles Maternal exposure Developmental toxicities Toxic mechanisms Safe-by-design |
| ISSN号 | 0264-1275 |
| 英文摘要 | With the increasing production and applications, silver nanoparticles (AgNPs) can be released into the air, water and soil environment, leading to direct exposure to human beings. Embryos and fetuses are more sensitive to en-vironmental pollutants than adults. Thus, the developmental toxicity of AgNPs should be of great concern. How-ever, the targets and molecular mechanisms how prenatal AgNP exposure affects fetal development in mammals are largely unknown. In the current review, the translocation and developmental toxicities of AgNPs upon mater-nal exposure in mammals are summarized. AgNPs are able to translocate to the fetus, resulting in resorption, growth retardation and histological and functional abnormalities in the fetal central nervous system (CNS), re-productive system, immune system and other systems and organs. A few likely mechanisms, including direct and indirect mechanisms, and knowledge gaps are elucidated. The fundamental physiochemical properties that determine their behaviors are discussed in order to develop safe-by-design nanomaterials for personal care and medical applications. This review aims to advance the understanding of the developmental toxicities of AgNPs for the design of nanomaterials that harbor better biocompatibility. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS研究方向 | Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45800]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong Acad Med Sci, Jinan 250117, Shandong, Peoples R China 2.Shandong First Med Univ, Affiliated Hosp 1, Jinan 250014, Shandong, Peoples R China 3.Shandong First Med Univ, Biomed Sci Coll, Jinan 250117, Shandong, Peoples R China 4.Shandong First Med Univ, Shandong Med Biotechnol Ctr, Jinan 250117, Shandong, Peoples R China 5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 6.Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jie,Liu, Sijin,Han, Jinxiang,et al. On the developmental toxicity of silver nanoparticles[J]. MATERIALS & DESIGN,2021,203:-. |
| APA | Zhang, Jie,Liu, Sijin,Han, Jinxiang,Wang, Zhe,&Zhang, Shuping.(2021).On the developmental toxicity of silver nanoparticles.MATERIALS & DESIGN,203,-. |
| MLA | Zhang, Jie,et al."On the developmental toxicity of silver nanoparticles".MATERIALS & DESIGN 203(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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