Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition
文献类型：期刊论文
| 作者 | Wang, Shunhao; Li, Jingchao; Chen, Mei; Ren, Liting; Feng, Wenya; Xu, Lining; Chen, Xiaolan; Xia, Tian; Zheng, Nanfeng; Liu, Sijin |
| 刊名 | NATIONAL SCIENCE REVIEW
 |
| 出版日期 | 2021-07 |
| 卷号 | 8期号:7页码:- |
| ISSN号 | 2095-5138 |
| 关键词 | palladium nanoplates tumor targeting lung metastasis epithelial-mesenchymal transition TGF-beta |
| 英文摘要 | Metastasis accounts for the majority of cancer deaths in many tumor types including breast cancer. Epithelial-mesenchymal transition (EMT) is the driving force for the occurrence and progression of metastasis, however, no targeted strategies to block the EMT program are currently available to combat metastasis. Diverse engineered nanomaterials (ENMs) have been reported to exert promising anti-cancer effects, however, no ENMs have been designed to target EMT. Palladium (Pd) nanomaterials, a type of ENM, have received substantial attention in nanomedicine due to their favorable photothermal performance for cancer therapeutics. Herein, Pd nanoplates (PdPL) were found to be preferentially biodistributed to both primary tumors and metastatic tumors. Importantly, PdPL showed a significant inhibition of lung metastasis with and without near-infrared (NIR) irradiation. Mechanistic investigations revealed that EMT was significantly compromised in breast cancer cells upon the PdPL treatment, which was partially due to the inhibition of the transforming growth factor-beta (TGF-beta) signaling. Strikingly, the PdPL was found to directly interact with TGF-beta proteins to diminish TGF-beta functions in activating its downstream signaling, as evidenced by the reduced phosphorylation of Smad2. Notably, TGF-beta-independent pathways were also involved in undermining EMT and other important biological processes that are necessary for metastasis. Additionally, NIR irradiation elicited synergistic effects on PdPL-induced inhibition of primary tumors and metastasis. In summary, these results revealed that the PdPL remarkably curbed metastasis by inhibiting EMT signaling, thereby indicating the promising potential of PdPL as a therapeutic agent for treating breast cancer metastasis. |
| WOS研究方向 | Multidisciplinary Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45804]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Xiamen Univ, Collaborat Innovat Ctr Chem Energy Mat, Dept Chem, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R Chi 5.Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Med, Div Nanomed, Los Angeles, CA 90095 USA |
| 推荐引用方式 GB/T 7714 | Wang, Shunhao,Li, Jingchao,Chen, Mei,et al. Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition[J]. NATIONAL SCIENCE REVIEW,2021,8(7):-. |
| APA | Wang, Shunhao.,Li, Jingchao.,Chen, Mei.,Ren, Liting.,Feng, Wenya.,...&Liu, Sijin.(2021).Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition.NATIONAL SCIENCE REVIEW,8(7),-. |
| MLA | Wang, Shunhao,et al."Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition".NATIONAL SCIENCE REVIEW 8.7(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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