Percutaneous penetration and dermal exposure risk assessment of chlorinated paraffins
文献类型：期刊论文
| 作者 | Gao, Wei ; Lin, Yongfeng; Liang, Yong; Wang, Yingjun; Jiang, Lu; Wang, Yawei; Jiang, Guibin
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-08-15 |
| 卷号 | 416页码:- |
| 关键词 | Chlorinated paraffins (CPs) Skin penetration Dermal exposure Risk assessment |
| ISSN号 | 0304-3894 |
| 英文摘要 | The widespread occurrence of chlorinated paraffins (CPs) in environmental matrices has resulted in a high frequency exposure to CPs via dermal contact. To quantitatively estimate percutaneous penetration of CPs, Episkin (R) human skin equivalents (HSE) was applied as an in vitro model to evaluate the mechanism of percutaneous penetration of CPs. The co-exposure of CPs mixtures to HSE showed that about 11.7% and 10.2% of short-chain CPs (SCCPs) and medium-chain CPs (MCCPs) could penetrate the HSE and enter the receptor fluid, while no long-chain CPs (LCCPs) (C 17) were able to penetrate the HSE during the 36-h assay period. The experimentally obtained permeability coefficient (Kp) values for CPs were significantly (p < 0.01) negatively correlated with their log octanol-water partition coefficient (log Kow). Furthermore, 24 participants were recruited to assess direct human dermal exposure to CPs in China with the total CPs collected onto hand wipes and forehead wipes being 96,600 and 30,400 ng/person, respectively. The proportion of total SCCPs and MCCPs intake via dermal penetration (skin area investigated in this study) accounting for 2.0% of the total intake of CPs. Considering the total skin surface of human body is around 20 times of the area studied, the total intake of CPs through dermal penetration could be a significant exposure pathway. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45806]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 3.Qingdao Univ, Sch Publ Hlth, Qingdao 266021, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 5.UCAS, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Wei,Lin, Yongfeng,Liang, Yong,et al. Percutaneous penetration and dermal exposure risk assessment of chlorinated paraffins[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,416:-. |
| APA | Gao, Wei.,Lin, Yongfeng.,Liang, Yong.,Wang, Yingjun.,Jiang, Lu.,...&Jiang, Guibin.(2021).Percutaneous penetration and dermal exposure risk assessment of chlorinated paraffins.JOURNAL OF HAZARDOUS MATERIALS,416,-. |
| MLA | Gao, Wei,et al."Percutaneous penetration and dermal exposure risk assessment of chlorinated paraffins".JOURNAL OF HAZARDOUS MATERIALS 416(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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