PM2.5 and the typical components cause organelle damage, apoptosis and necrosis: Role of reactive oxygen species
文献类型：期刊论文
| 作者 | Shan, Xifeng; Liu, Ling; Li, Gang; Xu, Kexin; Liu, Bingyan; Jiang, Wei |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2021-08-15 |
| 卷号 | 782页码:- |
| 关键词 | PM2.5 Reactive oxygen species Lysosomal membrane permeabilization Mitochondrial membrane potential Apoptosis Necrosis |
| ISSN号 | 0048-9697 |
| 英文摘要 | In this research, the organelle damage, apoptosis and necrosis induced by PM2.5, BC and Kaolin were studied using human bronchial epithelial (16HBE) cells. PM2.5, BC and Kaolin all induce cell death, LDH release and excess intracellular ROS generation. For the organelle injuries, Kaolin and high-dose PM2.5 (240 mu g/mL) cause lysosomal acidification, but BC causes lysosomal alkalization (lysosomal membrane permeabilization, LMP). BC and Kaolin cause the loss of mitochondrial membrane potential (MMP), while PM2.5 does not. For the cell death mode, PM2.5 causes both apoptosis and necrosis. However only necrosis has been detected in the BC and Kaolin treated groups, indicating the more severe cellular insult. Excess ROS generation is involved in the organelle damage and cell death. ROS contributes to the BC-induced LMP and necrosis, but does not significantly affect the Kaolin induced MMP loss and necrosis. Therefore, the BC component in PM2.5 may cause cytotoxicity via ROS-dependent pathways, the Kaolin component may damage cells via ROS-independent mechanisms such as strong interaction. The PM2.5-induced apoptosis and necrosis can be partially mitigated after the removal of ROS, indicating the existence of both the ROS-dependent and ROS-independent mechanisms due to the complicated PM2.5 components. BC represents the anthropogenic source component in PM2.5, while Kaolin represents the natural source component. Our results provide knowledge on the toxic mechanisms of typical PM2.5 components at the cellular and subcellular levels. (C) 2021 Elsevier B.V. All rights reserved. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45812]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong Univ, Environm Res Inst, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shan, Xifeng,Liu, Ling,Li, Gang,et al. PM2.5 and the typical components cause organelle damage, apoptosis and necrosis: Role of reactive oxygen species[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,782:-. |
| APA | Shan, Xifeng,Liu, Ling,Li, Gang,Xu, Kexin,Liu, Bingyan,&Jiang, Wei.(2021).PM2.5 and the typical components cause organelle damage, apoptosis and necrosis: Role of reactive oxygen species.SCIENCE OF THE TOTAL ENVIRONMENT,782,-. |
| MLA | Shan, Xifeng,et al."PM2.5 and the typical components cause organelle damage, apoptosis and necrosis: Role of reactive oxygen species".SCIENCE OF THE TOTAL ENVIRONMENT 782(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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